Nucleotide metabolism regulates human telomere length via telomerase activation

Telomere length is an important determinant of cellular aging and disease risk, but the genetics of telomere length control in humans is unclear. A genome-wide CRISPR screen has now identified a central role for thymidine nucleotide metabolism in the regulation of telomere length, which has implications for the diagnosis and treatment of disease.

Automated summary

Telomere length is a crucial factor affecting cellular aging and disease susceptibility, but the underlying genetics of telomere length regulation in humans remains poorly understood. A recent genome-wide CRISPR screen has identified the central involvement of thymidine nucleotide metabolism in telomere length regulation, highlighting its potential implications for disease diagnosis and treatment.