A goldilocks amount of H3K27me3

A study of drug-resistant lymphomas with hypermorphic mutations in PRC2 has identified a 'methylation index' by which cancer cells maintain optimal H3K27me3 levels for survival, emphasizing the importance of understanding how tumors adapt to changes in chromatin and to drug-resistance mutations.

Automated summary

A study on drug-resistant lymphomas reveals the existence of a 'methylation index' that enables cancer cells to maintain optimal H3K27me3 levels, highlighting the significance of comprehending tumor adaptation to chromatin changes and drug-resistance mutations.