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Article
Biochemistry & Molecular Biology
Hypercompact adenine base editors based on transposase B guided by engineered RNA
Do Yon Kim et al.
Summary: This study introduces a new technology called TaRGET, which utilizes engineered guide RNAs to activate the programmable endonuclease activity of TnpB. The researchers also developed TnpB-based adenine base editors and expanded the targetable sites using engineered variants of TnpB or optimized deaminases. TaRGET-ABE shows promising potential for precise genome-editing tools and CRISPR-based gene therapy.
NATURE CHEMICAL BIOLOGY (2022)
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