The pyrimidinosome is cancer's Achilles' heel

A new study shows that the enzymes involved in de novo pyrimidine synthesis and ferroptosis form a complex called the pyrimidinosome, which is controlled by AMPK. Cancer cells low in AMPK expression rely on the pyrimidinosome, suggesting that co-inhibition of AMPK and the pyrimidinosome represents a potential cancer treatment strategy.

Automated summary

A recent study reveals that the formation of a complex named pyrimidinosome, consisting of enzymes involved in de novo pyrimidine synthesis and ferroptosis, is controlled by AMPK. Cancer cells with low AMPK expression rely on pyrimidinosome, suggesting that co-inhibition of AMPK and pyrimidinosome might be a potential strategy for cancer treatment.