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Why gene therapies must go virus-free

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NATURE BIOTECHNOLOGY
卷 41, 期 6, 页码 737-739

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NATURE PORTFOLIO
DOI: 10.1038/s41587-023-01824-6

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Gene therapies have made remarkable progress in treating previously incurable diseases, but they are also the most expensive treatments worldwide. To address this issue, companies are replacing viruses in gene therapies with new delivery technologies, which not only overcome the limitations of viral vectors but also significantly reduce production costs.
Gene therapies have made spectacular progress in delivering new cures for previously intractable disease, but they remain the world's most expensive treatments. Now companies are replacing the virus in gene therapies with new delivery technologies that promise not only to overcome the limitations of viral vectors but to slash production costs too.

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