相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Functional stability of CFTR depends on tight binding of ATP at its degenerate ATP-binding site
Han- Yeh et al.
JOURNAL OF PHYSIOLOGY-LONDON (2021)
Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores
Avik K. Pati et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Structural identification of a hotspot on CFTR for potentiation
Fangyu Liu et al.
SCIENCE (2019)
Quantifying secondary transport at single-molecule resolution
Gabriel A. Fitzgerald et al.
NATURE (2019)
STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL
Laszlo Csanady et al.
PHYSIOLOGICAL REVIEWS (2019)
Structural mechanisms of CFTR function and dysfunction
Tzyh-Chang Hwang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2018)
Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent
Steven E. Van der Plas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O1 state
Emily Langron et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Molecular structure of the ATP-bound, phosphorylated human CFTR
Zhe Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Jasenko Zivanov et al.
ELIFE (2018)
A common mechanism for CFTR potentiators
Han-I Yeh et al.
JOURNAL OF GENERAL PHYSIOLOGY (2017)
Dynamics of P-type ATPase transport revealed by single-molecule FRET
Mateusz Dyla et al.
NATURE (2017)
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Shawn Q. Zheng et al.
NATURE METHODS (2017)
Conformational Changes of CFTR upon Phosphorylation and ATP Binding
Zhe Zhang et al.
CELL (2017)
Molecular Structure of the Human CFTR Ion Channel
Fangyu Liu et al.
CELL (2017)
Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator
Zhe Zhang et al.
CELL (2016)
Gctf: Real-time CTF determination and correction
Kai Zhang
JOURNAL OF STRUCTURAL BIOLOGY (2016)
Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale
Manuel F. Juette et al.
NATURE METHODS (2016)
Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization
Csaba Mihalyi et al.
ELIFE (2016)
Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate
Wen-Ying Lin et al.
MOLECULAR PHARMACOLOGY (2016)
Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels
Luiz A. Poletto Chaves et al.
JOURNAL OF GENERAL PHYSIOLOGY (2015)
Cystic fibrosis genetics: from molecular understanding to clinical application
Garry R. Cutting
NATURE REVIEWS GENETICS (2015)
A single amino acid substitution in CFTR converts ATP to an inhibitory ligand
Wen-Ying Lin et al.
JOURNAL OF GENERAL PHYSIOLOGY (2014)
Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator
Sabine Hadida et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
April Goehring et al.
NATURE PROTOCOLS (2014)
Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle
Kang-Yang Jih et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Ivacaftor potentiation of multiple CFTR channels with gating mutations
Haihui Yu et al.
JOURNAL OF CYSTIC FIBROSIS (2012)
Nonequilibrium Gating of CFTR on an Equilibrium Theme
Kang-Yang Jih et al.
PHYSIOLOGY (2012)
Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2
Andras Szollosi et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel
Ming-Feng Tsai et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations
Laszlo Csanady et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
ATP-independent CFTR channel gating and allosteric modulation by phosphorylation
Wei Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
ABC transporters: the power to change
Douglas C. Rees et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
An oxygen scavenging system for improvement of dye stability in single-molecule fluorescence experiments
Colin Echeverria Aitken et al.
BIOPHYSICAL JOURNAL (2008)
G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects
Silvia G. Bompadre et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics
Zhen Zhou et al.
JOURNAL OF GENERAL PHYSIOLOGY (2006)
The ABC protein turned chloride channel whose failure causes cystic fibrosis
DC Gadsby et al.
NATURE (2006)
Automated electron microscope tomography using robust prediction of specimen movements
DN Mastronarde
JOURNAL OF STRUCTURAL BIOLOGY (2005)
CFTR gating - II: Effects of nucleotide binding on the stability of open states
SG Bompadre et al.
JOURNAL OF GENERAL PHYSIOLOGY (2005)
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
P Vergani et al.
NATURE (2005)
ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity
CO Randak et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling
F Qin
BIOPHYSICAL JOURNAL (2004)
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating
C Basso et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
On the mechanism of MgATP-dependent gating of CFTR Cl- channels
P Vergani et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
The first nucleotide binding domain of cystic fibrosis transmembrane conductance regulator is a site of stable nucleotide interaction, whereas the second is a site of rapid turnover
L Aleksandrov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains
AC Powe et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)