4.8 Article

Co-opting signalling molecules enables logic-gated control of CAR T cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

GD2-CART cell therapy for H3K27M-mutated diffuse midline gliomas

Robbie G. Majzner et al.

Summary: Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are lethal pediatric tumors of the central nervous system. GD2-directed chimeric antigen receptor (CAR) T cells show promising preclinical efficacy. Four patients with H3K27M-mutated DIPG or spinal cord DMG were treated with GD2-CAR T cells and showed clinical and radiographic improvement.

NATURE (2022)

Article Biochemistry & Molecular Biology

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

Louai Labanieh et al.

Summary: SNIP CARs are a protease-based CAR platform that can regulate CAR activity using an FDA-approved small molecule. SNIP CAR-T cells exhibit higher potency and show reduced T cell exhaustion and enhanced stemness compared to constitutive CAR-T cells in various models. In a ROR1-based CAR lethality model, toxicity can be reversed by stopping the drug, and tumor eradication without toxicity can be achieved by reducing the drug dosage. SNIP CARs provide a solution to the safety and efficacy barriers currently limiting the use of CAR-T cells in treating solid tumors by enabling remote tuning of CAR activity.
Article Biotechnology & Applied Microbiology

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling

Caleb A. Lareau et al.

Summary: This study combines ATAC-seq and mitochondrial DNA sequencing to reveal clonal variation in human cells and tissues. It enables the inference of clonal relationships, mtDNA heteroplasmy, and chromatin variability in individual cells, linking epigenomic variability to subclonal evolution and cellular dynamics in vivo. Overall, this approach allows for the study of cellular population dynamics and clonal properties in vivo.

NATURE BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Article Medicine, General & Internal

Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study

Jesus G. Berdeja et al.

Summary: The study aimed to evaluate the safety and clinical activity of cilta-cel in patients with relapsed or refractory multiple myeloma, and the results showed that cilta-cel treatment achieved good efficacy and safety with short treatment duration, deep response, and long duration of response.

LANCET (2021)

Article Biochemistry & Molecular Biology

Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function

Alexander Salter et al.

Summary: CAR-modified T cell therapy is effective in treating certain hematological malignancies, but requires enhancements to target solid tumors with low antigen density. By examining T cell signaling, researchers were able to design CARs with improved antigen sensitivity, leading to enhanced efficacy in low antigen density environments.

SCIENCE SIGNALING (2021)

Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

Review Oncology

Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors

Giovanni Fuca et al.

CLINICAL CANCER RESEARCH (2020)

Article Biotechnology & Applied Microbiology

The therapeutic landscape for cells engineered with chimeric antigen receptors

Matthew MacKay et al.

NATURE BIOTECHNOLOGY (2020)

Review Oncology

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Sarwish Rafiq et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Oncology

Tuning the Antigen Density Requirement for CAR T-cell Activity

Robbie G. Majzner et al.

CANCER DISCOVERY (2020)

Article Multidisciplinary Sciences

Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor et al.

NATURE (2020)

Review Biotechnology & Applied Microbiology

CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?

Jessica Wagner et al.

MOLECULAR THERAPY (2020)

Article Multidisciplinary Sciences

Designed protein logic to target cells with precise combinations of surface antigens

Marc J. Lajoie et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

Clinical lessons learned from the first leg of the CAR T cell journey

Robbie G. Majzner et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Judith Feucht et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn et al.

NATURE (2019)

Review Immunology

ZAP-70 in Signaling, Biology, and Disease

Byron B. Au-Yeung et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

Article Biochemistry & Molecular Biology

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Jang Hwan Cho et al.

Article Biotechnology & Applied Microbiology

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Christopher C. Kloss et al.

MOLECULAR THERAPY (2018)

Review Medicine, General & Internal

Chimeric Antigen Receptor Therapy

Carl H. June et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Biochemistry & Molecular Biology

TCR Signaling: Mechanisms of Initiation and Propagation

Adam H. Courtney et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

Review Engineering, Biomedical

Programming CAR-T cells to kill cancer

Louai Labanieh et al.

NATURE BIOMEDICAL ENGINEERING (2018)

Review Immunology

CAR T cells for infection, autoimmunity and allotransplantation

Colby R. Maldini et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long et al.

NATURE MEDICINE (2015)

Article Biotechnology & Applied Microbiology

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

Christopher C. Kloss et al.

NATURE BIOTECHNOLOGY (2013)

Article Biochemical Research Methods

SPICE: Exploration and Analysis of Post-Cytometric Complex Multivariate Datasets

Mario Roederer et al.

CYTOMETRY PART A (2011)

Article Cell Biology

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

Lakshmi Balagopalan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

Sebastian Deindl et al.

Review Biochemistry & Molecular Biology

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

EH Palacios et al.

ONCOGENE (2004)

Article Biotechnology & Applied Microbiology

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor

J Maher et al.

NATURE BIOTECHNOLOGY (2002)