4.8 Article

Autoregulation of GPCR signalling through the third intracellular loop

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The G protein database, GproteinDb

Gaspar Pandy-Szekeres et al.

Summary: The G protein database offers reference data and tools for analysis, visualization, and design of scientific studies across disciplines and areas. This platform can help researchers translate new pharmacological, structural, and genomic data into insights on G protein signaling vital for human physiology and medicine. The database is accessible at https://gproteindb.org.

NUCLEIC ACIDS RESEARCH (2022)

Article Biochemistry & Molecular Biology

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Simon D. Harding et al.

Summary: The IUPHAR/BPS Guide to PHARMACOLOGY has expanded its content in the past two years, focusing on infection, malaria, and antibiotic resistance. It has included a new family of Coronavirus proteins and collaborated with Medicines for Malaria Venture and AntibioticDB to enhance coverage of malaria pharmacology and antibacterials.

NUCLEIC ACIDS RESEARCH (2022)

Article Biology

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

Charlotte Avet et al.

Summary: This study presents a set of BRET sensors to monitor the activation of G protein subtypes without modifying the receptors or G proteins. Profiling 100 therapeutically relevant human GPCRs resulted in pathway-specific concentration-response curves, revealing a diversity of coupling profiles.
Article Biochemistry & Molecular Biology

GPCRdb in 2021: integrating GPCR sequence, structure and function

Albert J. Kooistra et al.

Summary: GPCRdb is a database that serves over 4,000 researchers, providing a wide range of information and tools related to G protein-coupled receptors, including structural models, drug and ligand data. It continuously updates and improves its tools and resources for research and analysis.

NUCLEIC ACIDS RESEARCH (2021)

Article Biochemistry & Molecular Biology

GPCR activation mechanisms across classes and macro/microscales

Alexander S. Hauser et al.

Summary: The study identified molecular mechanistic maps of G-protein-coupled receptor activation in humans, revealing structural differences between different classes and laying the foundation for receptor-function studies and drug development.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus

Keehun Kim et al.

Summary: This study focuses on investigating the influence of ligand-dependent receptor conformation on G protein activation through biophysical methods. A new experimental approach combining SPASM FRET sensors and GPMV technology was developed to measure and analyze ligand molecular efficacy, confirming the receptor-G-peptide interaction as a significant structural determinant. Leveraging this technology, a two-stage receptor activation mechanism was elucidated through the combination of v-SPASM measurements and molecular dynamics simulations.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biology

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Adrian L. Sanborn et al.

Summary: 150 ADs were identified, with most (73%) binding to the Med15 subunit of Mediator, and binding strength correlated with activation. AD-Mediator interaction is a dynamic 'fuzzy' binding process without shape complementarity. Mutagenesis revealed biochemical and structural constraints, and a neural network accurately predicted ADs in human proteins and other yeast proteins.
Article Biochemistry & Molecular Biology

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Qiufeng Liu et al.

Summary: CCKAR is a G-protein-coupled receptor that regulates nutrient homeostasis by interacting with a sulfated ligand and coupling with different G-protein subtypes. The selectivity of G-protein coupling is determined by conformational differences in the G alpha subunits' 'wavy hook' and the ICL3 of the receptor.

NATURE CHEMICAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane

Ning Ma et al.

BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor

Sangbae Lee et al.

STRUCTURE (2019)

Article Biochemistry & Molecular Biology

Structural Insights into the Process of GPCR-G Protein Complex Formation

Xiangyu Liu et al.

Article Multidisciplinary Sciences

Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity

Manbir Sandhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Illuminating G-Protein-Coupling Selectivity of GPCRs

Asuka Inoue et al.

Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Biochemistry & Molecular Biology

The Molecular Basis of G Protein-Coupled Receptor Activation

William I. Weis et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Biochemical Research Methods

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

Jing Huang et al.

NATURE METHODS (2017)

Article Multidisciplinary Sciences

Selectivity determinants of GPCR-G-protein binding

Tilman Flock et al.

NATURE (2017)

Article Multidisciplinary Sciences

Priming GPCR signaling through the synergistic effect of two G proteins

Tejas M. Gupte et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

Understanding the GPCR biased signaling through G protein and arrestin complex structures

X. Edward Zhou et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

Matthew T. Eddy et al.

STRUCTURE (2016)

Article Chemistry, Physical

Structural Dynamics and Thermostabilization of Neurotensin Receptor 1

Sangbae Lee et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2015)

Article Biochemistry & Molecular Biology

Structured and disordered facets of the GPCR fold

A. J. Venkatakrishnan et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists

Richard Carr et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells

Rabia U. Malik et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Chemistry, Physical

Improved Parameters for the Martini Coarse-Grained Protein Force Field

Djurre H. de Jong et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Chemistry, Physical

MSMBuilder2: Modeling Conformational Dynamics on the Picosecond to Millisecond Scale

Kyle A. Beauchamp et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)

Article Multidisciplinary Sciences

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Soren G. F. Rasmussen et al.

NATURE (2011)

Article Multidisciplinary Sciences

Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor

Rouslan Moukhametzianov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

Yongfang Zhao et al.

NATURE (2010)

Review Biotechnology & Applied Microbiology

Monitoring protein interactions and dynamics with solvatochromic fluorophores

Galen S. Loving et al.

TRENDS IN BIOTECHNOLOGY (2010)

Review Cell Biology

Fine-tuning of GPCR activity by receptor-interacting proteins

Stefanie L. Ritter et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

Detergent binding explains anomalous SDS-PAGE migration of membrane proteins

Arianna Rath et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biotechnology & Applied Microbiology

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

Huanting Liu et al.

BMC BIOTECHNOLOGY (2008)

Article Chemistry, Physical

The MARTINI force field: Coarse grained model for biomolecular simulations

Siewert J. Marrink et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2007)

Article Biochemical Research Methods

Genetic incorporation of unnatural amino acids into proteins in mammalian cells

Wenshe Liu et al.

NATURE METHODS (2007)

Article Biochemistry & Molecular Biology

G protein-coupled receptors show unusual patterns of intrinsic unfolding

VP Jaakola et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2005)

Article Multidisciplinary Sciences

Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

L Covic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor

P Ghanouni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)