Parmoferone A, a new depsidone from the lichen Parmotrema cristiferum

A new depsidone, parmoferone A (1), together with three known compounds, parmosidone K (2), albifolione (3), and 4-chloroorcinol (4) were isolated from the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae). The structures of isolated compounds were identified from its spectroscopic data and by comparison with the literature. Compounds 1-4 were evaluated for alpha-glucosidase inhibition. Compound 1 was determined to be a potent non-competitive inhibitor against alpha-glucosidase with an IC50 value of 18.1 mu M.

Automated summary

A new depsidone, parmoferone A (1), along with three known compounds, parmosidone K (2), albifolione (3), and 4-chloroorcinol (4), were isolated from the lichen Parmotrema cristiferum. The structures of the compounds were determined through spectroscopic analysis and comparison with literature. The inhibitory activity of compounds 1-4 against alpha-glucosidase was evaluated, and compound 1 exhibited potent non-competitive inhibition with an IC50 value of 18.1 μM.