期刊
NATURAL PRODUCT RESEARCH
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2023.2188590
关键词
Sinoflavonoid; prenylated flavonoid; Podophyllum hexandrum; structure elucidation; anti-inflammatory
Two new prenylated flavonoids named sinoflavonoids NJ and NK (1-2), along with ten known compounds, were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ (1) with an unusual 5,11-dioxabenzo[b]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested for their anti-inflammatory activity using the LPS-induced RAW 264.7 mouse macrophages model. Sinoflavonoid NJ (1) showed the most potent inhibition on nitric oxide production with an IC50 value of 0.06 μM.
Two new prenylated flavonoids named sinoflavonoids NJ and NK (1-2), along with ten known compounds were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ (1) with an unusual 5,11-dioxabenzo[b]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ (1) showed the most potent inhibition on nitric oxide production with IC50 value as 0.06 mu M.
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