Three new isocoumarin analogues from an endolichenic fungus Aspergillus flavus CPCC 400810

Five isocoumarin derivatives including three new compounds, aspermarolides A-C (1-3), and two known analogues, 8-methoxyldiaporthin (4) and diaporthin (5) were obtained from the culture extract of Aspergillus flavus CPCC 400810. The structures of these compounds were elucidated by spectroscopic methods. The double bond geometry of 1 and 2 were assigned by the coupling constants. The absolute configuration of 3 was determined by electronic circular dichroism experiment. All compounds showed no cytotoxic activities against the two human cancer cells HepG2 and Hela.

Automated summary

Five isocoumarin derivatives, including three new compounds and two known analogues, were isolated from the culture extract of Aspergillus flavus CPCC 400810. The structures of these compounds were determined using spectroscopic methods. Compound 3's absolute configuration was confirmed by electronic circular dichroism experiment. All compounds exhibited no cytotoxic activity against HepG2 and Hela human cancer cells.