The significance of quercetin-loaded advanced nanoformulations for the management of diabetic wounds

Quercetin is a well-known plant flavanol that exhibits multiple biological activities, including antioxidant, anti-inflammatory and anticancer activities. The role of quercetin in wound healing has been widely explored by a range of researchers in different models. However, the physicochemical properties, such as solubility and permeability, of this compound are low, which ultimately limits its bioavailability on the target site. To overcome these limitations for successful therapy, scientists have developed a range of nanoformulations that provide effective therapeutic potential. In this review, the broad mechanism of quercetin for acute and chronic wounds is covered. A compilation of recent advances on the horizon of wound healing via quercetin is incorporated with several advanced nanoformulations.

Automated summary

Quercetin, a plant flavanol, has been found to have multiple biological activities including antioxidant, anti-inflammatory, and anticancer effects. However, its low solubility and permeability limit its bioavailability at the target site. To overcome these limitations, scientists have developed nanoformulations that enhance its therapeutic potential. This review summarizes the mechanisms of quercetin in wound healing and recent advances in using quercetin-loaded nanoformulations.