Neuroprotection of fullerene in improving cognitive-behavioral disruptions and neurobiochemical enzymes activities

Aim: Here, we report the synthesis and evaluation of fullerene C60 nanoparticles' (FC60 NPs') therapeutic efficacy in animals with aluminum-induced oxidative stress. Materials & methods: Effects of FC60 NPs on the altered activity levels of neurobiochemical enzymes and oxidative parameters in brain and liver tissues have been evaluated. Aluminum was injected for 3 weeks and from the beginning of the third week, FC60 NPs were injected for 1 week. Results: Administration of FC60 NPs showed a significant improvement in the altered activity level of the selected markers. Conclusion: Results suggest synthesized FC60 NPs as a therapeutic option for the treatment of neurodegenerative diseases.

Automated summary

This study reports the therapeutic efficacy of fullerene C60 nanoparticles (FC60 NPs) in animals with aluminum-induced oxidative stress. The effects of FC60 NPs on neurobiochemical enzymes and oxidative parameters in brain and liver tissues were evaluated. Results showed a significant improvement in the markers, suggesting FC60 NPs as a potential therapeutic option for neurodegenerative diseases.