4.8 Article

PtNi nano trilobal-based nanostructure with magnetocaloric oscillation and catalytic effects for pyroptosis-triggered tumor immunotherapy

期刊

NANO TODAY
卷 49, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2023.101769

关键词

Platinum-nickel bimetallic nanostructure; Pyroptosis; Magnetocaloric oscillation; Nanozyme catalytic activities; Tumor immunotherapy

向作者/读者索取更多资源

Researchers designed a PEGylated PtNi trilobal-shaped nanostructure for pyroptosis-triggered tumor immunotherapy through a nanozyme catalytic and magnetocaloric oscillation dual strategy. By applying an alternating magnetic field, the nanostructure generated hyperthermia and mechanical oscillation to activate the caspase-1-NLRP3-GSDMD pathway, leading to cell rupture and cytokine release, resulting in significant reduction of breast tumors.
Pyroptosis, a unique form of programmed cell death, has been verified to be linked to inflammatory diseases and malignant tumors. Although great achievements have been made in pyroptosis research, several gaps, such as innate drug resistance and severe toxicity, hinder the development of pyroptosis inducers for biomedical applications. Thus, in this study, we designed a polyethylene glycol (PEG)ylated platinum-nickel (PtNi) bimetallic trilobal-shaped nanostructure (PPTNS) for effective pyroptosis-triggered tumor im-munotherapy through a nanozyme catalytic and magnetocaloric oscillation dual strategy. Upon application of an alternating magnetic field, hyperthermia and mechanical oscillation of the specific sharp angles of PPTNS promoted damage-associated molecular pattern recognition, thereby activating the caspase-1-NLRP3-GSDMD pathway to increase cytokine recruitment. Furthermore, the high specific surface area and intrinsic nanozyme activities of PPTNS efficiently generated reactive oxygen species as the pathogen -as-sociated molecular pattern, thus stimulating pattern recognition receptors to accelerate the oligomerization of the NOD-like receptor NLRP3. By this dual strategy, pyroptosis was triggered to perforate the cell membrane, resulting in cell rupture and cytokine release. After two weeks of treatment, the sizes of the breast tumors were significantly reduced without noticeable long-term toxicity in vivo. This strategy pro-vides a magnetic-responsive platform for proptosis-triggered immunotherapy, which offers promising prospects for the highly efficient treatment of malignant tumors.(c) 2023 Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据