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Nanomedicine-based treatment: An emerging therapeutical strategy for pulmonary hypertension

NANO RESEARCH (2023)

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Article Biology

Catheterization of Pulmonary and Carotid Arteries for Concurrent Measurement of Mean Pulmonary and Systemic Arterial Pressure in Rat Models of Pulmonary Arterial Hypertension

Tanoy Sarkar et al.

Summary: This paper describes the surgical procedures for right heart catheterizations (RHC) to measure mean pulmonary arterial pressure (mPAP) in rats, as well as the catheterization of the carotid artery for simultaneous measurement of mPAP and mean systemic arterial pressure (mSAP) using the PowerLab Data Acquisition system. The protocol provided can be helpful for researchers to learn and replicate the microsurgical procedure for RHC in rats, and to measure mPAP and mSAP in rat models of pulmonary hypertension (PH) and other heart-related conditions.

BIO-PROTOCOL (2023)

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Article Chemistry, Physical

Metformin capped Cu2(OH)3Cl nanosheets for chemodynamic wound disinfection

Xueyu Wang et al.

Summary: By designing a new kind of Met-capped CuOHCl nanosheets, the bacteria can be effectively killed at low concentration and short treatment time, resulting in accelerated wound healing.

NANO RESEARCH (2023)

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Article Engineering, Biomedical

Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment

Qiong Huang et al.

Summary: Acute kidney injury (AKI) can lead to kidney function loss and increased mortality. This study discovers that ultra-small Tungsten-based nanodots (TWNDs) can be passively targeted for mitochondrial therapy in AKI, showing high effectiveness in reducing mitochondrial ROS and increasing mitophagy.

BIOACTIVE MATERIALS (2023)

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Review Engineering, Biomedical

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Qiaohui Chen et al.

Summary: This review article introduces the potential and advantages of nanodrugs in treating acute kidney injury (AKI). Traditional small molecule drugs have limitations in AKI treatment, while nanodrugs with kidney targeting ability can overcome these limitations and achieve significant therapeutic effects.

BIOACTIVE MATERIALS (2023)

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Article Chemistry, Multidisciplinary

PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response

Imran Ozer et al.

Summary: RNA aptamers are a promising class of therapeutics, but their poor blood circulation has limited their clinical potential. In this study, researchers address this limitation by conjugating RNA aptamers with a next-generation PEG-like brush polymer. The conjugate retains the therapeutic action of the drug and can be easily reversed, while avoiding the reactivity of pre-existing PEG antibodies. These findings have important implications for rescuing the PEGylation of RNA therapeutics and vaccines from the adverse effects of PEG.

ADVANCED MATERIALS (2022)

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Letter Critical Care Medicine

HIV-associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry

Nicholas A. Kolaitis et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Review Chemistry, Multidisciplinary

Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?

Ludivine Taiariol et al.

Summary: Click and bioorthogonal reactions are high-performance chemical reactions that have gained considerable attention in the biomedical field for the engineering of nanomedicines. This review compiles articles from 2014 to the present to highlight the application and main strategies of click chemistry and nanoparticles in biomedical applications.

CHEMICAL REVIEWS (2022)

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Article Pharmacology & Pharmacy

Targeted treprostinil delivery inhibits pulmonary arterial remodeling

Aijun Liu et al.

Summary: This study developed GlcA-modified liposomes to enhance the delivery of TPS to pulmonary arterial smooth muscle cells (PASMCs) and improve its effectiveness against PAH. The GlcA-liposomes significantly increased TPS bioavailability and sustained release, while also inhibiting PA remodeling and muscularization, decreasing PA medial thickening, suppressing collagen deposition, and attenuating right ventricle hypertrophy. In vitro experiments showed that GlcA-liposomes enhanced the inhibitory effects of TPS on PASMC proliferation and migration.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Respiratory System

The physiological basis of pulmonary arterial hypertension

Robert Naeije et al.

Summary: Pulmonary arterial hypertension is a rare condition characterized by increased pulmonary vascular resistance and right ventricular failure. Despite extensive pulmonary vascular remodeling, lung function is generally well preserved in patients with pulmonary arterial hypertension, with only mild changes in oxygen and carbon dioxide levels. Exercise limitation in pulmonary arterial hypertension is primarily due to cardiovascular issues rather than respiratory or muscular problems.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Respiratory System

Selexipag for the treatment of chronic thromboembolic pulmonary hypertension

Takeshi Ogo et al.

Summary: This study demonstrates that Selexipag can significantly improve pulmonary vascular resistance and other haemodynamic variables in patients with CTEPH, although exercise capacity remains unchanged.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension

Chao Teng et al.

Summary: This study aimed to co-deliver p53 gene and baicalein to PASMCs for alleviating PAH. The prepared system targeted PASMCs in vitro and enabled effective gene transfection, efficient apoptosis, and inflammation suppression. In vivo results showed that the co-delivery system could reverse monocrotaline-induced PAH.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Rheumatoid arthritis microenvironment insights into treatment effect of nanomaterials

Yan Zhu et al.

Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.

NANO TODAY (2022)

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Review Pharmacology & Pharmacy

Emerging Bismuth Chalcogenides Based Nanodrugs for Cancer Radiotherapy

Jia Huang et al.

Summary: This paper summarizes the latest progress of Bi2X3 nanodrugs in alleviating tumor hypoxic microenvironment to enhance radiotherapy. These nanodrugs can effectively overcome the resistance of radiation therapy and have high clinical application prospects.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Chemistry, Multidisciplinary

Polymer-Tethered Nanoparticles: From Surface Engineering to Directional Self-Assembly Published as part of the Accounts of Chemical Research special issue Self-Assembled Nanomaterials

Ning-Ning Zhang et al.

Summary: Current interest in nanoparticle ensembles is driven by their unique collective properties that surpass those of individual nanoparticles and bulk materials. Self-assembly provides a cost-effective way to create well-defined and predictable ensembles of nanoparticles. Polymer-functionalized nanoparticles are ideal building blocks for self-assembled nanostructures due to their similar dimensions and the ability to synthesize various types of polymers. Furthermore, polymer ligands can add additional functionalities to nanoparticle assemblies, expanding their range of applications.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Article Engineering, Biomedical

Mechanisms of selective monocyte targeting by liposomes functionalized with a cationic, arginine-rich lipopeptide

Rasmus Munter et al.

Summary: Stimulation of monocytes can be achieved by targeting them with cationic liposomes functionalized with a cholesterol-anchored tri-arginine peptide (TriArg). The specific targeting of monocytes is dependent on the content of TriArg in the liposomal membrane. Mechanistic findings reveal the involvement of the CD14 co-receptor in the selective monocyte targeting process.

ACTA BIOMATERIALIA (2022)

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Letter Critical Care Medicine

Inhaled Iloprost Improves Right Ventricular Load-Independent Contractility in Pulmonary Hypertension

Khodr Tello et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty

Ana Victoria Lechuga-Vieco et al.

Summary: This study demonstrates that divergent nonpathologic mtDNA heteroplasmy (DNPH) impairs mitochondrial function in critical tissues such as the heart and skeletal muscle, leading to severe pathology in adulthood. It suggests that potential incompatibilities between donor and recipient mtDNA should be considered in medical interventions.

CIRCULATION (2022)

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Review Cardiac & Cardiovascular Systems

The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure

Olivier Boucherat et al.

Summary: Pulmonary hypertension is a disease characterized by a mean pulmonary arterial pressure higher than 20 mm Hg. It is often associated with comorbidities and reduces life expectancy and quality of life. The current clinical classification divides pulmonary hypertension into five groups and there are currently no pharmacological cures for any form of the disease. Animal models are essential for studying the molecular mechanisms and testing new therapies, although their ability to fully replicate the complexity of human disease is limited. This review provides an overview of existing animal models and discusses approaches to improve their translational value.

CIRCULATION RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial

Trond J. Cooper et al.

Summary: This study investigated the safety and efficacy of the phosphodiesterase-5 inhibitor sildenafil in patients with heart failure and reduced ejection fraction (HFrEF) with indirect evidence of pulmonary hypertension (PHT). The results showed that sildenafil did not improve symptoms, quality of life, or exercise capacity compared to placebo in this patient population.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

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Article Cardiac & Cardiovascular Systems

Therapeutic augmentation of NO-sGC-cGMP signalling: lessons learned from pulmonary arterial hypertension and heart failure

Filippos Triposkiadis et al.

Summary: The NO-GC-cGMP pathway plays an important role in cardiovascular, pulmonary and renal function. PDE-5i and sGC stimulators are extensively used in PAH and HF. PDE-5i selectively dilate pulmonary blood vessels and are highly effective in PAH, but may have adverse effects in HF. sGC stimulators are effective in both PAH and HF due to their balanced pulmonary and systemic vasodilation.

HEART FAILURE REVIEWS (2022)

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Review Medicine, General & Internal

Diagnosis and Treatment of Pulmonary Arterial Hypertension A Review

Nicole F. Ruopp et al.

Summary: Pulmonary arterial hypertension, a subtype of pulmonary hypertension characterized by pulmonary arterial remodeling, can progress to right heart failure and death if left untreated. Approved therapies targeting multiple biological pathways have significantly improved survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Editorial Material Pharmacology & Pharmacy

Nanomedicine: controlling nanoparticle clearance for translational success

Geyunjian Harry Zhu et al.

Summary: Achieving complete clearance of nanoparticles is crucial in the design of safe and translatable nanomedicines. This article discusses recent developments in the field, focusing on renalclearable nano formulations with transformable sizes and alternative clearance mechanisms that enable controlled and efficient renal excretion.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

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Article Pharmacology & Pharmacy

SIRT 1 Activator Loaded Inhaled Antiangiogenic Liposomal Formulation Development for Pulmonary Hypertension

Sagar Dhoble et al.

Summary: Pulmonary hypertension is a disease characterized by increased pulmonary arterial pressure, and current treatments only provide symptomatic relief. This study developed a resveratrol liposomal dry powder formulation that can alleviate pulmonary arterial remodeling by inhibiting angiogenesis, suggesting a promising therapeutic strategy for treating pulmonary hypertension.

AAPS PHARMSCITECH (2022)

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Article Chemistry, Multidisciplinary

Piezotronic Effect-Augmented Cu2-x-O-BaTiO3 Sonosensitizers for Multifunctional Cancer Dynamic Therapy

Yunchao Zhao et al.

Summary: This study demonstrates the use of a Cu2-xO-BaTiO3 piezoelectric heterostructure as a sonosensitizer and chemodynamic agent for enhanced cancer therapy through ultrasound irradiation.

ACS NANO (2022)

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Article Cardiac & Cardiovascular Systems

Pulmonary vascular disease in pulmonary hypertension due to left heart disease: pathophysiologic implications

Kazunori Omote et al.

Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.

EUROPEAN HEART JOURNAL (2022)

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Review Chemistry, Multidisciplinary

Nanomedicine Strategies for Heating Cold Ovarian Cancer (OC): Next Evolution in Immunotherapy of OC

Yuqi Yang et al.

Summary: The article discusses the revolutionizing effects of immunotherapy on cancer treatment and the limitations of immunotherapy on ovarian cancer. Nanomedicines have shown promise in improving ovarian cancer treatment by reversing the cold tumor immune microenvironment.

ADVANCED SCIENCE (2022)

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Article Biophysics

State-of-the-art advancements in Liver-on-a-chip (LOC): Integrated biosensors for LOC

Min Liu et al.

Summary: Liver-on-a-chip (LOC), based on microfluidic technology, can simulate the physiological structure and microenvironment of the liver and incorporate biosensors for rapid responses. However, the professional barriers limit its wide application in liver disease research and drug screening for hepatotoxicity. This review comprehensively summarizes recent progress in LOC development and the embedding of biosensors, aiming to promote further research and exploit the potential value of this promising platform.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Oncology

Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy

Seyedeh Alia Moosavian et al.

Summary: This review highlights the challenges in translating liposomal delivery systems from preclinical studies to clinical application in cancer therapy. The gap between experimental results and practical use of liposomes is a major concern that needs to be addressed in order to improve the efficacy of this drug delivery system. Various potential approaches to overcome the barriers in clinical application of liposomal formulations are also discussed.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Multidisciplinary Sciences

Hydrogen sulfide and vascular regulation - An update

Boyang Lv et al.

Summary: This review summarizes the function of hydrogen sulfide (H2S) in vascular physiology and pathophysiology, including its role in regulating vascular tone, proliferation, apoptosis, and autophagy of vascular cells. The downregulation of H2S pathway is implicated in various vascular diseases, while H2S supplementation shows promise in preventing disease progression by regulating vascular tone, inhibiting inflammation, and protecting against oxidative stress. Additional research is needed to further understand the role of H2S in vascular physiology and pathophysiology.

JOURNAL OF ADVANCED RESEARCH (2021)

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Editorial Material Critical Care Medicine

In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension

Stuti Agarwal et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases

Zicheng Deng et al.

Summary: Nanoparticle delivery systems have been developed to address critical issues in the treatment of respiratory disorders, offering unique drug release capabilities and cell-targeting specificity. Low toxicity and high degradability are key requirements in nanoparticle design.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Inhaled bosentan microparticles for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats

Hyo-Jung Lee et al.

Summary: The feasibility of using inhalable bosentan microparticles as an alternative treatment for PAH was validated in this study, showing promising results in vitro and in vivo. The microparticles exhibited superior aerodynamic performance and dissolution rate compared to raw bosentan hydrate, with no evidence of lung toxicity. The intratracheal administration of SDBM 1:1 significantly improved pharmacokinetic parameters, pulmonary arterial remodeling, and right ventricular hypertrophy in a rat model of PAH.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Synergistic Enzyme Mixtures to Realize Near-Complete Depolymerization in Biodegradable Polymer/Additive Blends

Christopher DelRe et al.

Summary: Embedding catalysts in plastics can accelerate chemical modifications with programmable latency and pathways. By introducing additives to change the morphology of polymeric materials, it is possible to alter the accessibility of embedded enzymes to achieve near-complete degradation. Understanding how the host polymer's morphologies impact reactions catalyzed by embedded species is crucial for enhancing depolymerization processes.

ADVANCED MATERIALS (2021)

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Article Chemistry, Physical

Fundamental aspects of the non-covalent modification of cellulose via polymer adsorption

Vishnu Arumughan et al.

Summary: This review article discusses the non-covalent modification of cellulose fibers through the adsorption of functional polymers, focusing on fundamental aspects of polymer adsorption on cellulose surfaces. The correlation of adsorption findings with the Scheutjens-Fleer polymer adsorption theory provides insight into the phenomenon and its context in utilizing cellulose fibers. Studies on model surfaces and cellulose macro-fibers are reviewed to understand the potential of using this approach for tailored material properties.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Review Pharmacology & Pharmacy

Nanomedicine for the treatment of diabetes-associated cardiovascular diseases and fibrosis

Xiao-Min Luo et al.

Summary: Nanoparticles show great promise as a novel delivery system for treating heart failure in diabetes patients, with their unique advantages making them ideal for improving therapeutic efficacy and targeting specific pathways related to cardiomyopathy and fibrosis.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Editorial Material Critical Care Medicine

Risk Stratification in Pulmonary Arterial Hypertension: Do Not Forget the Patient Perspective

Marc Humbert et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Respiratory System

ERS statement on chronic thromboembolic pulmonary hypertension

Marion Delcroix et al.

Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism, often resulting in right heart failure. Current treatment modalities include surgery, angioplasty, and medication therapy.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Letter Cardiac & Cardiovascular Systems

Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice

Takayuki Fujiwara et al.

CIRCULATION (2021)

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Article Chemistry, Multidisciplinary

Microfluidic fabrication of inhalable large porous microspheres loaded with H2S-releasing aspirin derivative for pulmonary arterial hypertension therapy

Hui Zhang et al.

Summary: The designed microfluidics-assisted ACS14-containing LPMs have shown great potential to be used as an inhalable and efficacious H2S donor in the treatment of PAH.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Medicine, General & Internal

Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease

Aaron Waxman et al.

Summary: In patients with pulmonary hypertension due to interstitial lung disease, inhaled treprostinil significantly improved exercise capacity and clinical outcomes compared to placebo in a 16-week trial. Adverse events such as cough, headache, dyspnea, dizziness, nausea, fatigue, and diarrhea were commonly reported.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Health Care Sciences & Services

Digital Tracking of Physical Activity, Heart Rate, and Inhalation Behavior in Patients With Pulmonary Arterial Hypertension Treated With Inhaled Iloprost: Observational Study (VENTASTEP)

Barbara Stollfuss et al.

Summary: By digitally tracking physical parameters of patients with pulmonary arterial hypertension starting treatment with iloprost, this study aimed to investigate correlations between changes in digital physical activity measures and changes in traditional clinical measures and health-related quality of life. Results suggest that parallel monitoring of physical activity, heart rate, and iloprost inhalation is feasible in patients with pulmonary arterial hypertension and may complement traditional measures in guiding treatment, despite the limitations of the study's sample size.

JOURNAL OF MEDICAL INTERNET RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Three- Versus Two-Drug Therapy for Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Kelly M. Chin et al.

Summary: The study compared the efficacy and safety of initial triple oral therapy with initial double oral therapy in newly diagnosed PAH patients, finding that both treatment strategies were equally effective in reducing pulmonary vascular resistance, but initial triple oral therapy may potentially improve long-term outcomes.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Respiratory System

Endothelial cells in the pathogenesis of pulmonary arterial hypertension

Colin E. Evans et al.

Summary: Pulmonary arterial hypertension is a devastating disease characterized by pulmonary vasculopathy that leads to increased pulmonary vascular resistance and right heart failure. Recent studies suggest that endothelial cells play a crucial role in the initiation and progression of PAH, affecting various pathophysiological processes in the disease progression.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Nanoscience & Nanotechnology

In vivo Pharmacokinetics and in vitro Release of Imatinib Mesylate-Loaded Liposomes for Pulmonary Delivery

Hongfei Xu et al.

Summary: The study developed IM-loaded liposomes for pulmonary delivery to treat PAH, showing potential applications and promising outcomes. The IM-LPs demonstrated nanosized ranges and sustained release of IM, indicating potential for therapeutic use in pulmonary delivery.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Chemistry, Multidisciplinary

Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy

Ying Zhu et al.

Summary: The study found that using a liposomal system based on ginsenoside Rg3 can effectively improve the targeting of brain tumors, enhance the delivery of drugs, and play a beneficial role in anti-tumor treatment.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Dose-Independent Transfection of Hydrophobized Polyplexes

Zhen Zhang et al.

Summary: The stability and endocytosis pathway of cationic polymer complexes determine their transfection dose-dependence. Polyplexes with optimal hydrophobicity can remain integrated at low concentrations and enter cells via macropinocytosis, achieving dose-independent DNA transfection.

ADVANCED MATERIALS (2021)

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Article Critical Care Medicine

Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances

Bradley A. Maron et al.

Summary: The diagnosis and management of pulmonary arterial hypertension have seen advances in early diagnosis, multiple pharmacotherapeutics, and new risk factors becoming focal points. Developmental biology may be useful in predicting incident PAH.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

A statistical framework for determination of minimal plasmid copy number required for transgene expression in mammalian cells

Liangli Wang et al.

Summary: Plasmid DNA is commonly used for non-viral gene delivery, but only a fraction of molecules function as transcription templates in the nucleus. Researchers developed a statistical framework to establish the minimal amount of pDNA molecules needed for transgene expression. Experimental data under different conditions could be quantitatively explained or predicted using this framework.

BIOELECTROCHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Nanozymes for regulation of reactive oxygen species and disease therapy

Yujie Dai et al.

Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.

CHINESE CHEMICAL LETTERS (2021)

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Article Cardiac & Cardiovascular Systems

ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension

Dan Li et al.

Summary: Our studies have uncovered a metabolic-transcriptional axis explaining how dividing cells use ALDH1A3 to coordinate their energy needs with the epigenetic and transcriptional regulation of genes required for SMC proliferation. They suggest that selectively disrupting the pivotal role of ALDH1A3 in PAH SMC, but not endothelial cells, is an important therapeutic consideration.

CIRCULATION (2021)

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Review Engineering, Biomedical

MoS2-based nanocomposites for cancer diagnosis and therapy

Jianling Wang et al.

Summary: Molybdenum is an essential trace element for human survival. MoS2-nanomaterials have unique properties that make them attractive for cancer diagnosis and treatment, such as adsorbing biomolecules and drugs for improved targeting and accuracy, as well as excellent photothermal conversion efficiency for therapy.

BIOACTIVE MATERIALS (2021)

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Article Medicine, General & Internal

Sotatercept for the Treatment of Pulmonary Arterial Hypertension

Marc Humbert et al.

Summary: In this study, patients with pulmonary arterial hypertension receiving Sotatercept treatment showed a significant reduction in pulmonary vascular resistance at 24 weeks, with both Sotatercept groups performing better than the placebo group.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Critical Care Medicine

Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial

Marius M. Hoeper et al.

Summary: The study compared the effects of switching to riociguat from PDE5i therapy versus continuing PDE5i therapy in PAH patients at intermediate risk of 1-year mortality. Results showed higher clinical improvement rates and lower clinical worsening events in the riociguat group, indicating that switching to riociguat could be a strategic treatment escalation option for these patients.

LANCET RESPIRATORY MEDICINE (2021)

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Review Pharmacology & Pharmacy

Emerging strategies in developing multifunctional nanomaterials for cancer nanotheranostics

Melgious Jin Yan Ang et al.

Summary: The review focuses on recent developments of advanced nanomaterials and nanotheranostics in cancer treatment, particularly in the areas of stimulus-responsive nanomaterials and nanocarriers targeting the tumor microenvironment. The review also discusses the potential cytotoxicity and future prospects of next-generation nanomaterials for clinical implementation.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications

Zhirong Liu et al.

Summary: Electroactive biomaterials have the potential to mimic cell microenvironments and regulate cell and tissue behaviors for tissue regeneration. Electrical stimulation can impact various biological processes and is crucial for nerve, bone, and cardiac tissue regeneration.

ADVANCED MATERIALS (2021)

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Review Chemistry, Physical

Advances in amphiphilic polylactide/vinyl polymer based nano-assemblies for drug delivery

Didier Gigmes et al.

Summary: Amphiphilic copolymer micelles are key candidates in drug delivery, with PLA-based micelles and controlled radical polymerizations offering new opportunities for advanced drug delivery systems. Key properties such as stealth character, cell targeting and stimuli-responsiveness have been advanced in the past decade for PLA/vinyl polymer based nano-carriers.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Editorial Material Critical Care Medicine

Upfront Combination Therapy for Pulmonary Arterial Hypertension: Time to Be More Ambitious than AMBITION

Thomas M. Cascino et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Critical Care Medicine

Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension

Athenais Boucly et al.

Summary: The study findings suggest that initial triple combination therapy containing parenteral prostacyclin is associated with a higher survival rate in patients with PAH, particularly in younger high-risk patients.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

Taijyu Satoh et al.

Summary: This study elucidated the mechanisms through which metabolic syndrome contributes to pulmonary vascular dysfunction and exercise-induced pulmonary hypertension in patients with heart failure with preserved ejection fraction. Restoring NFYA-sGC beta 1-cGMP signaling can ameliorate EIPH.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia

Fei Sun et al.

Summary: Nanoparticle therapies increasing neonatal pulmonary angiogenesis may prevent pulmonary hypertension in patients with ACDMPV, improving survival rates and decreasing fibrotic lung remodeling.

CIRCULATION (2021)

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Review Pharmacology & Pharmacy

Novel nanomedicines to overcome cancer multidrug resistance

Zhenwei Su et al.

Summary: Chemotherapy is powerful in eliminating malignant cells, but its efficacy is often hindered by drug resistance. Nanomedicine, focusing on targeted drug delivery to tumor tissues using nano-sized formulations, shows promise in improving treatment outcomes, minimizing adverse effects, and overcoming cancer drug resistance. This approach involves strategies such as passive and active targeted delivery, delivering multidrug combinations, and multimodal combination therapy to pave the way for effective cancer treatment and holds great potential in overcoming drug resistance.

DRUG RESISTANCE UPDATES (2021)

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Review Oncology

Nanomaterials for cancer therapy: current progress and perspectives

Zhe Cheng et al.

Summary: Nanomaterials play an important role in cancer therapy by targeting cancer cells, tumor microenvironment, and the immune system. However, despite an increasing number of studies, the approval of nano-drugs has not significantly increased, requiring further research to improve clinical translation efficiency.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Chemistry, Physical

Obstacles and opportunities in a forward vision for cancer nanomedicine

Irene de Lazaro et al.

Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.

NATURE MATERIALS (2021)

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Review Nanoscience & Nanotechnology

The current landscape of nucleic acid therapeutics

Jayesh A. Kulkarni et al.

Summary: The increasing number of approved nucleic acid therapeutics demonstrates their potential for long-lasting or curative effects by targeting genetic blueprints; however, their clinical translation relies on advances in delivery technologies. Four platform technologies, including antisense oligonucleotides, small interfering RNA conjugates, lipid nanoparticles, and adeno-associated virus vectors, have enabled the clinical translation of nucleic acid therapeutics, leading to the approval of cutting-edge genetic drugs.

NATURE NANOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice

Kathleen Marulanda et al.

Summary: The study developed peptide amphiphile nanofibers that target lung tissue with pulmonary hypertension, demonstrating the potential of a RAGE-targeted nanomaterial as a drug delivery platform to treat the disease. The targeted nanofibers significantly accumulated in the lungs, showing specific localization to diseased pulmonary tissue and reduced off-target toxicity.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Nanoscience & Nanotechnology

Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Shuncheng Yao et al.

Summary: Covalent organic frameworks (COFs) are porous and crystalline materials with diverse characteristics, making them excellent candidate materials for biomedical applications such as drug delivery, diagnostic imaging, and disease therapy. The components, dimensions, and guest molecule loading into COFs have a great influence on their performance in various applications, requiring further investigation.

NANO-MICRO LETTERS (2021)

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Article Critical Care Medicine

Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study

Steven D. Nathan et al.

Summary: The INCREASE trial demonstrated that inhaled treprostinil improved FVC in patients with ILD and associated pulmonary hypertension, with more significant effects observed in specific subgroups, suggesting its potential as a therapeutic option for pulmonary fibrosis.

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, Research & Experimental

Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension

Wenrui Ma et al.

Summary: The study revealed that miR-30a was significantly upregulated in PAH patients, and genetic knockout of miR-30a effectively reduced pathological features of PAH in animal models. Pharmacological inhibition of miR-30a via intratracheal liquid instillation showed promising therapeutic outcomes for PAH treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Cell Biology

Hydrogen Sulfide Metabolism and Pulmonary Hypertension

Lukas Roubenne et al.

Summary: Pulmonary hypertension is a severe disease with no curative treatment available, but hydrogen sulfide (H2S) has been shown to have protective effects against it by regulating hypoxia response and mitochondrial bioenergetics, among other pathways. This suggests that H2S could be a relevant target for new therapeutic strategies.

CELLS (2021)

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Review Chemistry, Multidisciplinary

Inorganic nanomaterials with rapid clearance for biomedical applications

Xianwen Wang et al.

Summary: Inorganic nanomaterials have great potential in biomedicine, but long-term accumulation in healthy tissues can cause toxicity. The emergence of biodegradable and clearable inorganic nanomaterials provides a way to prevent such toxicity, and a comprehensive understanding of their design and metabolic pathways is essential for expanding therapeutic applications for various diseases.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Critical Care Medicine

Risk Reduction and Right Heart Reverse Remodeling by Upfront Triple Combination Therapy in Pulmonary Arterial Hypertension

Michele D'Alto et al.

CHEST (2020)

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Review Pharmacology & Pharmacy

Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease

Nikolaos Tzoumas et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Article Chemistry, Multidisciplinary

Feedback-controlled photolytic gas phase nitric oxide delivery from S-nitrosothiol-doped silicone rubber films

Gergely Lautner et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Physical

Potential application of liposomal nanodevices for non-cancer diseases: an update on design, characterization and biopharmaceutical evaluation

Fereshteh Bayat et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

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Article Surgery

High levels of dd-cfDNA identify patients with TCMR 1A and borderline allograft rejection at elevated risk of graft injury

Erik Stites et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Letter Respiratory System

Transition from intravenous epoprostenol to selexipag in pulmonary arterial hypertension: a word of caution

Kenichi Yanaka et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Pharmacology & Pharmacy

Treatment of pulmonary hypertension with riociguat: a review of current evidence and future perspectives

Afroditi K. Boutou et al.

EXPERT OPINION ON PHARMACOTHERAPY (2020)

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Article Cardiac & Cardiovascular Systems

Ambrisentan in portopulmonary hypertension: A multicenter, open-label trial

Ioana R. Preston et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Editorial Material Cardiac & Cardiovascular Systems

The challenge of an expanded therapeutic window in pulmonary hypertension

Simon Stewart et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Multidisciplinary Sciences

Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

Hebah A. Sindi et al.

NATURE COMMUNICATIONS (2020)

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Article Rheumatology

Initial combination therapy of ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) in the modified intention-to-treat population of the AMBITION study: post hoc analysis

Masataka Kuwana et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Review Pharmacology & Pharmacy

Nanomedicine to target multidrug resistant tumors

Elise Lepeltier et al.

DRUG RESISTANCE UPDATES (2020)

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Editorial Material Respiratory System

IL-6 in pulmonary hypertension: why novel is not always best

Mark Toshner et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Letter Respiratory System

Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension

Olivier Sitbon et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Biochemistry & Molecular Biology

MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension

Susana Carregal-Romero et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Chemistry, Multidisciplinary

Safety Considerations of Cancer Nanomedicine-A Key Step toward Translation

Xiangsheng Liu et al.

SMALL (2020)

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Article Instruments & Instrumentation

Challenges in nanomedicine clinical translation

Josbert M. Metselaar et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Review Pharmacology & Pharmacy

Liposomes: Advancements and innovation in the manufacturing process

Sanket Shah et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Critical Care Medicine

TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2

Ye Fan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Periostin A Potential Therapeutic Target For Pulmonary Hypertension?

Xiaowei Nie et al.

CIRCULATION RESEARCH (2020)

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Review Biochemical Research Methods

Recent trends in nanopore polymer functionalization

Robert Brilmayer et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

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Review Nanoscience & Nanotechnology

Molecular Design of Layer-by-Layer Functionalized Liposomes for Oral Drug Delivery

Wing-Fu Lai et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Pharmacology & Pharmacy

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

Duhyeong Hwang et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Chemistry, Multidisciplinary

Tumor-Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity

Ju Hee Ryu et al.

ADVANCED MATERIALS (2020)

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Article Multidisciplinary Sciences

Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway

Lin Mei et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Delivering the power of nanomedicine to patients today

Matthieu Germain et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Medicine, General & Internal

Pulmonary Hypertension: A Brief Guide for Clinicians

Stacy A. Mandras et al.

MAYO CLINIC PROCEEDINGS (2020)

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Review Oncology

The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies

Magdalena Gebert et al.

CANCERS (2020)

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Article Cell Biology

Amorphous nano-selenium quantum dots prevent pulmonary arterial hypertension through recoupling endothelial nitric oxide synthase

Mo-Li Zhu et al.

Aging-US (2020)

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Article Pharmacology & Pharmacy

DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment

Zerong Li et al.

DRUG DELIVERY (2020)

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Article Cardiac & Cardiovascular Systems

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension

Qiujun Yu et al.

CIRCULATION (2019)

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Article Biochemistry & Molecular Biology

Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction

Qiang Li et al.

REDOX BIOLOGY (2019)

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Article Critical Care Medicine

The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia

Arun Pradhan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Pharmacology & Pharmacy

Comparison of different chemically modified inhibitors of miR-199b in vivo

Burcu Duygu et al.

BIOCHEMICAL PHARMACOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Preparation and characterization of bosentan monohydrate/ε-polycaprolactone nanoparticles obtained by electrospraying

Virna M. Gimenez et al.

BIOTECHNOLOGY PROGRESS (2019)

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Article Cardiac & Cardiovascular Systems

CLIC4/Arf6 Pathway A New Lead in BMPRII Inhibition in Pulmonary Hypertension

Vahitha B. Abdul-Salam et al.

CIRCULATION RESEARCH (2019)

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Article Cardiac & Cardiovascular Systems

Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function

Ignacio Fernando Hall et al.

CIRCULATION RESEARCH (2019)

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Article Peripheral Vascular Disease

Targeted Delivery of Sildenafil for Inhibiting Pulmonary Vascular Remodeling

Bingbing Li et al.

HYPERTENSION (2019)

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Article Respiratory System

Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension

R. James White et al.

RESPIRATORY RESEARCH (2019)

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Article Medicine, Research & Experimental

CAR, a Homing Peptide, Prolongs Pulmonary Preferential Vasodilation by Increasing Pulmonary Retention and Reducing Systemic Absorption of Liposomal Fasudil

Ali Keshavarz et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

PLGA Spherical Nucleic Acids

Shengshuang Zhu et al.

ADVANCED MATERIALS (2018)

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Editorial Material Critical Care Medicine

How Many FOXs Are There on The Road to Pulmonary Hypertension?

Kurt R. Stenmark et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Article Engineering, Biomedical

Site-selective protein modification with polymers for advanced biomedical applications

Xinyu Liu et al.

BIOMATERIALS (2018)

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Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

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Article Respiratory System

Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension

Pierre-Simon Bellaye et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH

Jahidur Rashid et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Pharmacology & Pharmacy

Cerivastatin Nanoliposome as a Potential Disease Modifying Approach for the Treatment of Pulmonary Arterial Hypertension

Young Lee et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

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Review Biochemistry & Molecular Biology

ROS signaling and ER stress in cardiovascular disease

Cristhiaan D. Ochoa et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

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Article Medicine, Research & Experimental

Fasudil and DETA NONOate, Loaded in a Peptide-Modified Liposomal Carrier, Slow PAH Progression upon Pulmonary Delivery

Jahidur Rashid et al.

MOLECULAR PHARMACEUTICS (2018)

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Review Medicine, General & Internal

Pulmonary arterial hypertension: pathogenesis and clinical management

Thenappan Thenappan et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

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Review Medicine, General & Internal

Pulmonary arterial hypertension: pathogenesis and clinical management

Thenappan Thenappan et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Nanoparticle-Mediated Targeting of Pitavastatin to Small Pulmonary Arteries and Leukocytes by Intravenous Administration Attenuates the Progression of Monocrotaline-Induced Established Pulmonary Arterial Hypertension in Rats

Kenzo Ichimura et al.

INTERNATIONAL HEART JOURNAL (2018)

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Review Pharmacology & Pharmacy

Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat

Reiner Frey et al.

CLINICAL PHARMACOKINETICS (2018)

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Article Chemistry, Multidisciplinary

Light-Responsive Biodegradable Nanorattles for Cancer Theranostics

Chunxiao Li et al.

ADVANCED MATERIALS (2018)

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Review Pharmacology & Pharmacy

Lipid-based carriers for controlled delivery of nitric oxide

Mahmoud A. Elnaggar et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

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Article Pharmacology & Pharmacy

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension

Victor Segura-Ibarra et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Exploring polyvinylpyrrolidone in the engineering of large porous PLGA microparticles via single emulsion method with tunable sustained release in the lung: In vitro and in vivo characterization

Rui Ni et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Medicine, Research & Experimental

Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency

Nilesh Gupta et al.

MOLECULAR PHARMACEUTICS (2017)

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Review Cardiac & Cardiovascular Systems

Epidemiology and treatment of pulmonary arterial hypertension

Edmund M. T. Lau et al.

NATURE REVIEWS CARDIOLOGY (2017)

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Article Nanoscience & Nanotechnology

ATG101 Single-Stranded Antisense RNA-Loaded Triangular DNA Nanoparticles Control Human Pulmonary Endothelial Growth via Regulation of Cell Macroautophagy

Juan Du et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Medicinal

Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles

Jaleh Varshosaz et al.

RESEARCH IN PHARMACEUTICAL SCIENCES (2017)

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Article Pharmacology & Pharmacy

Respirable controlled release polymeric colloid (RCRPC) of bosentan for the management of pulmonary hypertension: in vitro aerosolization, histological examination and in vivo pulmonary absorption

Lydia A. Hanna et al.

DRUG DELIVERY (2017)

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Review Pharmacology & Pharmacy

Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry

Rong Ni et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Chemistry, Multidisciplinary

Liposomal Aerosols of Nitric Oxide (NO) Donor as a Long-Acting Substitute for the Ultra-Short-Acting Inhaled NO in the Treatment of PAH

Kamrun Nahar et al.

PHARMACEUTICAL RESEARCH (2016)

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Review Critical Care Medicine

A global view of pulmonary hypertension

Marius M. Hoeper et al.

LANCET RESPIRATORY MEDICINE (2016)

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Article Engineering, Biomedical

Regulation of vascular smooth muscle cell autophagy by DNA nanotube-conjugated mTOR siRNA

Zaichun You et al.

BIOMATERIALS (2015)

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Article Cardiac & Cardiovascular Systems

Delivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Pulmonary Arterial Hypertension

Satoshi Akagi et al.

International Heart Journal (2015)

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Article Pharmacology & Pharmacy

Fasudil and SOD packaged in peptide-studded-liposomes: Properties, pharmacokinetics and ex-vivo targeting to isolated perfused rat lungs

Nilesh Gupta et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Chemistry, Multidisciplinary

Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

Jared M. McLendon et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension

Tomoaki Ishihara et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Critical Care Medicine

Novel and Emerging Therapies for Pulmonary Hypertension

Soni Savai Pullamsetti et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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Article Engineering, Biomedical

Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension

Madhukar B. Kolli et al.

BIOMATERIALS (2014)

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Article Nanoscience & Nanotechnology

Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries

Pritesh P. Jain et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

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Article Pharmacology & Pharmacy

Starch-coated magnetic liposomes as an inhalable carrier for accumulation of fasudil in the pulmonary vasculature

Kamrun Nahar et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Chemistry, Medicinal

Peptide-Micelle Hybrids Containing Fasudil for Targeted Delivery to the Pulmonary Arteries and Arterioles to Treat Pulmonary Arterial Hypertension

Nilesh Gupta et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

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Article Medicine, Research & Experimental

Peptide-Coated Liposomal Fasudil Enhances Site Specific Vasodilation in Pulmonary Arterial Hypertension

Kamrun Nahar et al.

MOLECULAR PHARMACEUTICS (2014)

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Article Biochemistry & Molecular Biology

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

Rajkumar Savai et al.

NATURE MEDICINE (2014)

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Article Nanoscience & Nanotechnology

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

James E. Dahlman et al.

NATURE NANOTECHNOLOGY (2014)

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Review Genetics & Heredity

Non-viral vectors for gene-based therapy

Hao Yin et al.

NATURE REVIEWS GENETICS (2014)

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Article Chemistry, Multidisciplinary

Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension

Vivek Gupta et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Nanoscience & Nanotechnology

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Anna Salvati et al.

NATURE NANOTECHNOLOGY (2013)

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Article Chemistry, Multidisciplinary

The Potential Efficacy of R8-Modified Paclitaxel-Loaded Liposomes on Pulmonary Arterial Hypertension

Yujia Yin et al.

PHARMACEUTICAL RESEARCH (2013)

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Article Pharmacology & Pharmacy

Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice

Huili Zhang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

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Editorial Material Multidisciplinary Sciences

MATERIALS CHEMISTRY Liposomes derived from molecular vases

Cyrus R. Safinya et al.

NATURE (2012)

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Article Pathology

Peptide-Directed Highly Selective Targeting of Pulmonary Arterial Hypertension

Takeo Urakami et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

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Article Oncology

miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc

Zhe Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)

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Article Peripheral Vascular Disease

Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension

Satoshi Kimura et al.

HYPERTENSION (2009)

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