4.8 Article

Immunostimulant nanomodulator boosts antitumor immune response in triple negative breast cancer by synergism of vessel normalization and photothermal therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Genetically Engineered Hematopoietic Stem Cells Deliver TGF-β Inhibitor to Enhance Bone Metastases Immunotherapy

Beilei Wang et al.

Summary: This study demonstrates the use of genetically engineered hematopoietic stem cells (HSCs) expressing PD1 to deliver TGF-beta inhibitor to bone metastases. This strategy changes the immune microenvironment of the bone marrow and enhances anti-tumor immunity, showing great promise for the treatment of bone metastases.

ADVANCED SCIENCE (2022)

Article Engineering, Environmental

Photothermal nanobomb blocking metabolic adenosine-A2AR potentiates infiltration and activity of T cells for robust antitumor immunotherapy

Yuetao Zhao et al.

Summary: Researchers have developed a novel immunostimulant nanomaterial containing a black phosphorus nanobomb, which can efficiently suppress the growth of melanoma through photothermal therapy and blockade of metabolic immune pathways.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Chemistry, Multidisciplinary

Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity

Xiang Ling et al.

Summary: The combination of antiangiogenesis and chemotherapy regimens with cancer immunotherapy using bioresponsive nanoparticles could inhibit angiogenesis, induce tumor cell apoptosis, and activate immune responses in tumor microenvironments, thus promoting antitumor immunity and inhibiting tumor growth.

ACS NANO (2021)

Review Chemistry, Multidisciplinary

Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy

Mengyu Chang et al.

Summary: Hyperthermia therapy has emerged as a strategy against malignant tumors, particularly when combined with nanomaterial-based photothermal therapy or magnetic hyperthermia. While these treatments alone may not completely cure cancer, when combined with cancer immunotherapy, they have shown potential for enhanced therapeutic outcomes against both primary tumors and metastatic lesions, as well as preventing cancer recurrence and prolonging survival period.

ADVANCED MATERIALS (2021)

Review Nanoscience & Nanotechnology

Nanomaterials for T-cell cancer immunotherapy

Ningqiang Gong et al.

Summary: T-cell-based immunotherapies show promise in treating cancer, but face challenges such as insufficient expansion of transferred T cells and inefficient trafficking into tumors. Nanomaterials offer a solution to enhance T-cell therapy by overcoming physical barriers and modulating tumor microenvironments.

NATURE NANOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Immunomodulatory Layered Double Hydroxide Nanoparticles Enable Neurogenesis by Targeting Transforming Growth Factor-β Receptor 2

Rongrong Zhu et al.

Summary: The study evaluated the effects of Mg/Al layered double hydroxide (Mg/Al-LDH) nanoparticles on neural regeneration and immunoregulation in spinal cord injury (SCI) recovery. LDH demonstrated significant capabilities in promoting neural stem cell migration and differentiation, activating L-Ca2+ channels, and generating inducible action potentials, while inhibiting inflammatory responses and accelerating neural regeneration through TGFBR2.

ACS NANO (2021)

Review Oncology

The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker

Denis L. Jardim et al.

Summary: Tumor mutational burden (TMB) reflects cancer mutation quantity and correlates with better outcomes of immune checkpoint inhibitors (ICIs). However, TMB as a biomarker is imperfect and a composite predictor including critical variables is needed.

CANCER CELL (2021)

Article Chemistry, Multidisciplinary

Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control Over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy

Hong-Bo Cheng et al.

Summary: This study developed a novel reversible photodynamic therapy switch for controlling the production of singlet oxygen, providing a potential strategy for photodynamic-immunotherapy.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Engineering, Biomedical

Physiologically triggered injectable red blood cell-based gel for tumor photoablation and enhanced cancer immunotherapy

Ziying Fei et al.

Summary: An injectable gel based on red blood cells was developed for cancer photo-immunotherapy, demonstrating a durable systemic immune response and tumor rejection in mice, highlighting the potential of using RBCs for drug delivery and cancer treatment.

BIOMATERIALS (2021)

Review Chemistry, Multidisciplinary

Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

Shan Gao et al.

Summary: Immunotherapy utilizing the human immune system against cancer has become a mainstream strategy, with the potential to eliminate tumors and treat metastasis and recurrence. The development of nanotechnology has enabled the application of nanomaterials in cancer immunotherapy, offering significant potential for improving treatment efficacy. Nanotechnology-based immunotherapy aims to produce effective anti-tumor immune responses and enhance tumor immune defense by modulating the immune suppression mechanism in the tumor microenvironment.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Photothermal-Chemotherapy Enhancing Tumor Immunotherapy by Multifunctional Metal-Organic Framework Based Drug Delivery System

Weidong Ni et al.

Summary: Immunotherapy shows promise for tumor treatment, but its clinical effect is limited by tumor immunogenicity and the immunosuppressive microenvironment. Researchers combined metal-organic framework MIL-100 loaded with mitoxantrone (MTO) with photothermal-chemotherapy to enhance immunogenic cell death. The resulting MMH NPs, with dual therapeutic properties and imaging modes, showed high antitumor efficacy and immune effect when co-injected with anti-OX40 antibody in colorectal cancer. This novel combined therapeutic strategy is promising for future tumor therapy.

NANO LETTERS (2021)

Article Nanoscience & Nanotechnology

Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Ximing Shao et al.

Summary: The study reveals a tumoricidal mechanism of black phosphorus nanomaterials where they directly affect the mitotic centrosome machinery by suppressing polo-like kinase 1, suggesting that nanomaterials can be applied in targeted cancer therapy with their intrinsic nano-bio properties.

NATURE NANOTECHNOLOGY (2021)

Correction Multidisciplinary Sciences

Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy (vol 7, 12967, 2016)

Jundong Shao et al.

NATURE COMMUNICATIONS (2021)

Article Engineering, Biomedical

Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition

Mohammad Taleb et al.

Summary: The study demonstrates the use of peptide nanoparticles to modulate both tumor vasculature and immune systems for synergistic tumor suppression. Increasing intratumoral infiltration of immune cells through vascular normalization, while simultaneously inhibiting the PD-L1 immune checkpoint function, reactivates effective immune responses against tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Heat-Confined Tumor-Docking Reversible Thermogel Potentiates Systemic Antitumor Immune Response During Near-Infrared Photothermal Ablation in Triple-Negative Breast Cancer

Vishnu Revuri et al.

Summary: A thermal ablation immunotherapy strategy was developed to prevent the immune suppressive effects of myeloid derived suppressor cells during photothermal ablation, inducing a durable systemic antitumor immunity to eradicate TNBC tumors. The injectable hydrogel BAGEL-R848 showed promising results in reducing tumor burden, promoting dendritic cell maturation, and enriching inflammatory M1 macrophages and CD8+IFN+ CTL to prevent metastatic tumor growth in a bilateral 4T1 tumor model.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Biochemistry & Molecular Biology

Therapeutic applications of AS1411 aptamer, an update review

Rezvan Yazdian-Robati et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Chemistry, Multidisciplinary

Two-Dimensional Nanomaterials for Photothermal Therapy

Shuang Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Chemistry, Inorganic & Nuclear

Functional nucleic acids for cancer theranostics

Tianhuan Peng et al.

COORDINATION CHEMISTRY REVIEWS (2020)

Review Immunology

Top 10 Challenges in Cancer Immunotherapy

Priti S. Hegde et al.

IMMUNITY (2020)

Article Multidisciplinary Sciences

TGF-β suppresses type 2 immunity to cancer

Ming Liu et al.

NATURE (2020)

Article Multidisciplinary Sciences

Cancer immunotherapy via targeted TGF-β signalling blockade in THcells

Shun Li et al.

NATURE (2020)

Review Pharmacology & Pharmacy

Manipulation of immune-vascular crosstalk: new strategies towards cancer treatment

Yang Zhao et al.

ACTA PHARMACEUTICA SINICA B (2020)

Review Chemistry, Multidisciplinary

Molecular and nanoengineering approaches towards activatable cancer immunotherapy

Chi Zhang et al.

CHEMICAL SOCIETY REVIEWS (2020)

Review Oncology

Inflammatory microenvironment remodelling by tumour cells after radiotherapy

Martin McLaughlin et al.

NATURE REVIEWS CANCER (2020)

Review Immunology

Enhancing cancer immunotherapy with nanomedicine

Darrell J. Irvine et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Tumour-intrinsic resistance to immune checkpoint blockade

Anusha Kalbasi et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Materials Science, Multidisciplinary

Nanomaterials as photothermal therapeutic agents

Junqi Chen et al.

PROGRESS IN MATERIALS SCIENCE (2019)

Review Physiology

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

John D. Martin et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

Article Medicine, Research & Experimental

Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Tina Gruosso et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Chemistry, Multidisciplinary

Combining Nanomedicine and Immunotherapy

Yang Shi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Review Biotechnology & Applied Microbiology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Jerome Galon et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Chemistry, Multidisciplinary

2D Black Phosphorus-Based Biomedical Applications

Miaomiao Luo et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Article Chemistry, Multidisciplinary

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Qian Chen et al.

ADVANCED MATERIALS (2019)

Review Oncology

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy

Jonathan J. Havel et al.

NATURE REVIEWS CANCER (2019)

Review Engineering, Biomedical

Physical oncology: New targets for nanomedicine

Alba Nicolas-Boluda et al.

BIOMATERIALS (2018)

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

Review Chemistry, Physical

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

Hua Wang et al.

NATURE MATERIALS (2018)

Article Chemistry, Multidisciplinary

Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics

Wei Tao et al.

ADVANCED MATERIALS (2017)

Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

Article Chemistry, Multidisciplinary

Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification

Guangbo Qu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Oncology

Targeting TGF-β Signaling in Cancer

Selcuk Colak et al.

TRENDS IN CANCER (2017)

Article Chemistry, Multidisciplinary

Surface Coordination of Black Phosphorus for Robust Air and Water Stability

Yuetao Zhao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Engineering, Biomedical

An overview of the effective combination therapies for the treatment of breast cancer

Cristina Nunez et al.

BIOMATERIALS (2016)

Review Oncology

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Giampaolo Bianchini et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Review Pharmacology & Pharmacy

Therapeutic targets of triple-negative breast cancer: a review

Vinayak S. Jamdade et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Review Biotechnology & Applied Microbiology

Targeting the TGFβ signalling pathway in disease

Rosemary J. Akhurst et al.

NATURE REVIEWS DRUG DISCOVERY (2012)