期刊
NANO LETTERS
卷 23, 期 9, 页码 4039-4048出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.3c00829
关键词
Modularized theranostic system; Sandwiched plasmonic chip; NIR-II fluorescence-guided surgery; Tumor-positive lymph nodes
A modular theranostic system combining NIR-II FGS and a sandwiched plasmonic chip (SPC) was developed for intraoperative detection and resection of tumor cells in lymph nodes with high sensitivity and selectivity. The system achieved accurate diagnosis and improved efficiency of cancer therapy.
Radical lymphadenectomy remains the cornerstone of preventing tumor metastasis through the lymphatic system. Current surgical resection of lymph nodes (LNs) based on fluorescence-guided surgery (FGS) suffers from low sensitivity/ selectivity with only qualitative information, hampering accurate intraoperative decision-making. Herein, we develop a modularized theranostic system including NIR-II FGS and a sandwiched plasmonic chip (SPC). Intraoperative NIR-II FGS and detection of tumor-positive lymph nodes were performed on the gastric tumor to determine the feasibility of the modularized theranostic system in defining LN metastasis. Under the NIR-II imaging window, the orthotopic tumor and sentinel lymph nodes (SLNs) were successfully excised without ambient light interference in the operating room. Importantly, the SPC biosensor achieved 100% sensitivity and 100% specificity for tumor markers and realized rapid and high-throughput intraoperative SLN detection. We propose the synergetic design of combining the NIR-II FGS and suitable biosensor will substantially improve the efficiency of cancer diagnosis and therapy follow-up.
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