☆ 4.8 Article

The Combination of Sinusoidal Perfusion Enhancement and Apoptosis Inhibition by Riociguat Plus a Galactose-PEGylated Bilirubin Multiplexing Nanomedicine Ameliorates Liver Fibrosis Progression

NANO LETTERS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Physical

Application of biocompatible custom ceria nanoparticles in improving the quality of liver grafts for transplantation

Yinbiao Qiao et al.

Summary: This study found that ceria nanoparticles can alleviate ischemia-reperfusion injury after liver transplantation by scavenging reactive oxygen species and promote liver function recovery. The experiment showed that ceria nanoparticles attenuated hypoxia reoxygenation- or H2O2-induced hepatocyte injury by enhancing mitochondrial activity and scavenging reactive oxygen species. This protective effect may be associated with the activation of the Nrf2/Keap1/HO-1 signaling pathway.

NANO RESEARCH (2023)

添加到收藏夹

Article Nanoscience & Nanotechnology

Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis

Mengying Hu et al.

Summary: The study reveals the key role of hepatic macrophages in mediating relaxation-induced alleviation of liver fibrosis. By developing lipid nanoparticles that target activated hepatic stellate cells and encapsulate relaxin gene and miR-30a-5p mimic, a synergistic antifibrosis effect is achieved in mouse liver fibrosis models. This approach demonstrates a proof-of-concept for devising antifibrotic strategies through the complementary application of nanotechnology and basic science.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1

Hong Wu et al.

Summary: The study demonstrates that TIPE1 plays a protective role in hepatocytes by inhibiting specific signaling pathways to reduce hepatocyte steatosis, inflammation, and fibrosis during the NASH process, suggesting it as a potential therapeutic target for NAFLD.

HEPATOLOGY (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Targeting cell-intrinsic metabolism for antifibrotic therapy

Helene Gilgenkrantz et al.

Summary: Recent years have seen significant advances in understanding the mechanisms of fibrosis progression and regression, emphasizing the necessity of metabolic reprogramming to support the energetic and anabolic demands of cellular changes. Targeting cell-intrinsic metabolic modifications of key fibrogenic cells can impact fibrosis progression, and there is potential for antifibrogenic interventions targeting metabolism.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling

Guozhi Bi et al.

Summary: The study showed that the activated ZAR1 protein can form pentameric complexes in the plasma membrane, exhibiting ion channel activity dependent on the conserved acidic residue Glu11. Pre-assembled ZAR1 resistosome readily incorporated into planar lipid-bilayers and displayed calcium-permeable cation-selective channel activity. Activation of ZAR1 in the plant cell resulted in Glu11-dependent Ca2+ influx, perturbation of subcellular structures, production of reactive oxygen species, and cell death.

CELL (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

Virender Kumar et al.

Summary: Type 2 diabetes mellitus associated non-alcoholic fatty liver disease is the fourth leading cause of death, with complications such as nephropathy and cirrhosis. Etiological factors involve hyperglycemia and insulin resistance, with treatment targets including FFA homeostasis and lipid metabolism. Strategies to enhance drug delivery to specific liver cell types have the potential to improve efficacy and reduce off-target effects.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Article Chemistry, Physical

Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

Yonghyun Lee et al.

NATURE MATERIALS (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Stephen A. Harrison et al.

JOURNAL OF HEPATOLOGY (2020)

添加到收藏夹

Review Genetics & Heredity

ASK1 inhibition: a therapeutic strategy with multi-system benefits

Jacqueline M. Ogier et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Protective Antioxidant Effects of Amentoflavone and Total Flavonoids fromHedyotis diffusaon H2O2-Induced HL-O2 Cells through ASK1/p38 MAPK Pathway

Yun-Lan Li et al.

CHEMISTRY & BIODIVERSITY (2020)

添加到收藏夹

Review Cell Biology

The Endothelium as a Driver of Liver Fibrosis and Regeneration

Erica Lafoz et al.

CELLS (2020)

添加到收藏夹

Article Chemistry, Physical

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

Hongxia Liang et al.

NANO RESEARCH (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bilirubin nanomedicine alleviates psoriatic skin inflammation by reducing oxidative stress and suppressing pathogenic signaling

Hyeongseop Keum et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct-ligated rats

Ksenia Brusilovskaya et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

Maria J. Perugorria et al.

GUT (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

The hepatic-targeted, resveratrol loaded nanoparticles for relief of high fat diet-induced nonalcoholic fatty liver disease

Wendi Teng et al.

JOURNAL OF CONTROLLED RELEASE (2019)

添加到收藏夹

Article Medicine, Research & Experimental

The potential role of vascular alterations and subsequent impaired liver blood flow and hepatic hypoxia in the pathophysiology of non-alcoholic steatohepatitis

D. van der Graaff et al.

MEDICAL HYPOTHESES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis

Hong-liang Liu et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

Rohit Loomba et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

Philipp Schwabl et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Gastroenterology & Hepatology

Role of inflammatory response in liver diseases: Therapeutic strategies

Jose A. Del Campo et al.

WORLD JOURNAL OF HEPATOLOGY (2018)

添加到收藏夹

Article Physiology

Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes

Jing Liu et al.

FRONTIERS IN PHYSIOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells

Young-Sun Lee et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multistimuli-Responsive Bilirubin Nanoparticles for Anticancer Therapy

Yonghyun Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences

Kati Richter et al.

REDOX BIOLOGY (2015)

添加到收藏夹

Article Medicine, Research & Experimental

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic

Chris J. Weston et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

添加到收藏夹

Review Multidisciplinary Sciences

Therapeutic targets in the ASK1-dependent stress signaling pathways

Ryoichi Hayakawa et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis

C Corpechot et al.

HEPATOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.