4.8 Article

Intranasal Pathway for Nanoparticles to Enter the Central Nervous System

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Nanoscience & Nanotechnology

Gold Nanorods with Spatial Separation of CeO2 Deposition for Plasmonic-Enhanced Antioxidant Stress and Photothermal Therapy of Alzheimer's Disease

Kezhen Ge et al.

Summary: This study explored the application of ceria nanoparticles in the treatment of Alzheimer's disease (AD). By introducing photothermal effect and photocatalytic activity, the treatment efficacy was improved. Biocompatibility and therapeutic effectiveness of Aβ-targeted inhibitory peptide-modified nanocomposites were verified in vitro and in vivo, suggesting the significant potential of nanotechnology in AD therapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Nanoscience & Nanotechnology

Anchoring Group-Mediated Radiolabeling of Inorganic Nanoparticles-A Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes

Jianxian Ge et al.

Summary: This study demonstrates the universality of a simple and efficient radiolabeling method, LAGMERAL, for constructing radioactive nanoprobes. The method utilizes a diphosphonate-polyethylene glycol (DP-PEG) group on the surface of inorganic nanoparticles for efficient radiolabeling. The resulting nanoprobes exhibit high radiolabeling stability and biocompatibility, making them promising for sensitive tumor diagnosis. This research highlights the importance and potential of LAGMERAL in nuclear medicine imaging.

ACS APPLIED MATERIALS & INTERFACES (2022)

Review Nanoscience & Nanotechnology

Drug delivery to the central nervous system

Elizabeth Nance et al.

Summary: The central nervous system is protected by tightly regulated physiological barriers, making drug delivery into the brain and spinal cord very challenging. This Review discusses the pathophysiological changes that complicate drug delivery into the central nervous system and examines materials-based strategies to bypass or overcome these barriers for drug delivery.

NATURE REVIEWS MATERIALS (2022)

Article Engineering, Biomedical

Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβ clearance

Zhongxiong Fan et al.

Summary: In this study, we successfully fabricated metformin-based supramolecular nanodrugs with an A beta-responsive on-demand drug release for synergistic Alzheimer's disease therapy. The nanodrugs exhibited outstanding physiological stability and selectively penetrated the blood-brain barrier to target microglia and neurons. The released drugs, metformin and donepezil, showed a superior synergistic anti-dementia effect by enhancing microglial phagocytosis and A beta clearance.

BIOMATERIALS (2022)

Article Chemistry, Multidisciplinary

Lipoprotein-Inspired Nanoscavenger for the Three-Pronged Modulation of Microglia-Derived Neuroinflammation in Alzheimer's Disease Therapy

Huaqing Zhang et al.

Summary: This study highlights the role of microglia in Alzheimer's disease and provides a promising tactic for modulating microglial dysfunction. By using a nanoscavenger, the researchers were able to accelerate Aβ catabolism and normalize microglial dysfunction, resulting in reversal of memory deficit and neuroinflammation in a mouse model of the disease.

NANO LETTERS (2022)

Article Chemistry, Multidisciplinary

Drug-Carrier Synergy Therapy for Amyloid-β Clearance and Inhibition of Tau Phosphorylation via Biomimetic Lipid Nanocomposite Assembly

Guochen Han et al.

Summary: This study presents a drug-carrier synergy therapy strategy using lipid nanocomposites to simultaneously target A beta and Tau-associated pathways for Alzheimer's disease (AD) treatment. The nanocomposites were modified with Ang ligands to enhance blood-brain barrier penetration and A beta clearance. Methylene blue was incorporated to inhibit Tau aggregation. The results showed that the strategy effectively reduced A beta levels and p-Tau levels, relieved AD symptoms, and improved cognitive functions in AD mouse models.

ADVANCED SCIENCE (2022)

Article Chemistry, Multidisciplinary

Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer?s Disease

Kang Qian et al.

Summary: Mitochondrial dysfunction in Alzheimer's disease has shown promise as a therapeutic target. This study developed a multifunctional hybrid peptide HNSS and a suitable peptide delivery system to repair and protect mitochondria, leading to improved outcomes in disease-related damage.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy

Xiaotong Yang et al.

Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with no effective treatment. In this study, a multifunctional nanocarrier was developed to deliver beta-site precursor protein cleaving enzyme-1 (BACE1) siRNA and rapamycin into the brain via intranasal administration. The results showed that this nanocarrier significantly improved the cognitive ability of transgenic AD mice.
Review Nanoscience & Nanotechnology

Recent Advances of Magnetic Nanomaterials for Bioimaging, Drug Delivery, and Cell Therapy

Ali Mohsin et al.

Summary: This review comprehensively outlines the advancements in the field of magnetic nanoparticles (MNPs) in stem cell therapy and nanomaterial-cell-based therapies. The review discusses the tracking, labeling, and improvement of physicochemical properties of MNPs, as well as their applications in cancer, cardiovascular, neurodegenerative, and bone-related disorders.

ACS APPLIED NANO MATERIALS (2022)

Article Chemistry, Multidisciplinary

A Microfluidics-Based Scalable Approach to Generate Extracellular Vesicles with Enhanced Therapeutic MicroRNA Loading for Intranasal Delivery to Mouse Glioblastomas

Kai Wang et al.

Summary: A scalable microfluidic platform was developed to load therapeutic miRNAs and drugs into EVs while controlling their size, leading to improved treatment outcomes in orthotopic GBM mouse models. The engineered mpEVs demonstrated efficient delivery of miRNAs and drugs to GBM cells, resulting in tumor regression and increased survival rates in mice, showing potential for clinical translation in GBM therapy.

ACS NANO (2021)

Review Biochemistry & Molecular Biology

Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics

Steven T. Proulx

Summary: Cerebrospinal fluid is produced in the ventricles of the brain and circulates through the subarachnoid space of the skull and spinal column to provide buoyancy and maintain fluid homeostasis. Recent studies challenge the traditional belief that CSF drains through arachnoid villi, suggesting it may instead flow through lymphatic vessels.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Chemistry, Multidisciplinary

Nanomedicine Directs Neuronal Differentiation of Neural Stem Cells via Silencing Long Noncoding RNA for Stroke Therapy

Bingling Lin et al.

Summary: A theranostic nanomedicine has been developed to co-deliver super-paramagnetic iron oxide nanoparticles (SPIO) and small interfering RNA/antisense oligonucleotides (siRNA/ASO) targeting Pnky long noncoding RNA (lncRNA) into neural stem cells (NSCs). This nanomedicine promotes neuronal differentiation of NSCs by silencing the Pnky lncRNA, while also enabling in vivo tracking of NSCs with improved magnetic resonance imaging. The enhanced neuronal differentiation of NSCs leads to structural and functional recovery of the damaged brain after a stroke, demonstrating potential for enhancing stem cell-based therapies for stroke.

NANO LETTERS (2021)

Article Chemistry, Multidisciplinary

Upregulating Aggregation-Induced-Emission Nanoparticles with Blood-Tumor-Barrier Permeability for Precise Photothermal Eradication of Brain Tumors and Induction of Local Immune Responses

Ming Zhang et al.

Summary: The study introduces a new type of nanoparticles, BK@AIE NPs, which can enhance transportation and accumulation inside tumors by activating BTB adenosine receptors. These nanoparticles can be used in photothermal therapy to treat deep-seated tumors and inhibit tumor progression, resulting in an extended survival span for mice.

ADVANCED MATERIALS (2021)

Article Pharmacology & Pharmacy

Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model-Protocol Development

Michael C. Veronesi et al.

Summary: The fate of radiolabeled polymeric micellar nanoparticles for nose-to-brain delivery was tracked using PET/CT imaging in a rat model, showing increased activity in the brain following intranasal drug delivery compared to intravenous administration at 1 and 2 hours post administration. Despite limitations, an experimental protocol for aerosolized intranasal delivery is presented for better targeting the olfactory epithelium.

PHARMACEUTICS (2021)

Review Chemistry, Multidisciplinary

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Mauro Sousa de Almeida et al.

Summary: Nanoparticles have diverse applications, particularly in nanomedicine for detecting and treating diseases like cancer and inflammation. Understanding the mechanisms of cellular uptake and intracellular localization of nanoparticles is crucial for therapeutic applications. Factors such as physicochemical properties, endocytic pathways, and cellular uptake regulators play key roles in the application of nanoparticles in medicine.

CHEMICAL SOCIETY REVIEWS (2021)

Article Cell Biology

Meningeal lymphatic vessels regulate brain tumor drainage and immunity

Xueting Hu et al.

CELL RESEARCH (2020)

Article Chemistry, Multidisciplinary

A Novel Targeted and High-Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease

Han Yang et al.

ADVANCED SCIENCE (2020)

Article Clinical Neurology

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

Qiaoli Ma et al.

ACTA NEUROPATHOLOGICA (2019)

Article Multidisciplinary Sciences

Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice

K. T. Householder et al.

SCIENTIFIC REPORTS (2019)

Review Engineering, Biomedical

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Jinbing Xie et al.

BIOMATERIALS (2019)

Review Chemistry, Multidisciplinary

Emerging blood-brain-barrier-crossing nanotechnology for brain cancer theranostics

Wei Tang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Chemistry, Multidisciplinary

MRI-Visible siRNA Nanomedicine Directing Neuronal Differentiation of Neural Stem Cells in Stroke

Liejing Lu et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Review Medicine, Research & Experimental

Mechanism of intranasal drug delivery directly to the brain

Tyler P. Crowe et al.

LIFE SCIENCES (2018)

Review Biochemistry & Molecular Biology

Advances in Meningeal Immunity

Rejane Rua et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Neurosciences

Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Andreas Bjorefeldt et al.

FRONTIERS IN NEURAL CIRCUITS (2018)

Review Chemistry, Multidisciplinary

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Denzil Furtado et al.

ADVANCED MATERIALS (2018)

Review Immunology

The unique structural and functional features of CXCL12

Rik Janssens et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

Article Chemistry, Multidisciplinary

A strategy for bypassing the blood-brain barrier: Facial intradermal brain-targeted delivery via the trigeminal nerve

Xi-Chong Yu et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Chemistry, Multidisciplinary

Progress in brain targeting drug delivery system by nasal route

Abdur Rauf Khan et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Neurosciences

ROLE OF CHOROID PLEXUS IN CEREBROSPINAL FLUID HYDRODYNAMICS

Darko Oreskovic et al.

NEUROSCIENCE (2017)

Review Chemistry, Multidisciplinary

Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery

Benjami Oller-Salvia et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Endocrinology & Metabolism

Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration

Jeffrey J. Lochhead et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Multidisciplinary Sciences

Structural and functional features of central nervous system lymphatic vessels

Antoine Louveau et al.

NATURE (2015)

Review Neurosciences

Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence

Stephen B. Hladky et al.

FLUIDS AND BARRIERS OF THE CNS (2014)

Article Chemistry, Multidisciplinary

Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood-Brain Barrier

Ruirui Qiao et al.

ACS NANO (2012)

Review Pharmacology & Pharmacy

Intranasal delivery of biologics to the central nervous system

Jeffrey J. Lochhead et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Pharmacology & Pharmacy

Intranasal delivery of insulin via the olfactory nerve pathway

Dan B. Renner et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2012)

Review Oncology

Molecularly targeted therapies for malignant gliomas: advances and challenges

Marto Penas-Prodo et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2007)

Article Pharmacology & Pharmacy

Visualization of in vivo olfactory uptake and transfer using fluorescein dextran

B Jansson et al.

JOURNAL OF DRUG TARGETING (2002)

Review Radiology, Nuclear Medicine & Medical Imaging

Trigeminal nerve: anatomy and pathology

P Woolfall et al.

BRITISH JOURNAL OF RADIOLOGY (2001)