4.3 Article

Green Synthesis, Characterization and Biocompatibility Study of Quercetin-Functionalized Biogenic Silver Nanoparticles

期刊

NANO
卷 18, 期 7, 页码 -

出版社

WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793292023500558

关键词

Silver nanoparticles; quercetin; Evolvulus alsinoides; apoptosis; functionalization

向作者/读者索取更多资源

In this study, quercetin functionalized biogenic silver nanoparticles (Qur-EA-AgNPs) were synthesized using Evolvulus alsinoides leaf extract. The biocompatibility of Qur-EA-AgNPs was investigated and the results showed that they have good biocompatibility and exhibit antimicrobial and anticancer activity.
Silver nanoparticles (AgNPs) occupy a major part in biomedicine due to their unique physicochemical and biological properties including anti-microbial and anti-cancer activity. Evolvulus alsinoides (EA), commonly known as Dwarf morning glory, is a flowering plant with unique medicinal properties. This plant is reported for its therapeutic significance in chronic bronchitis, asthma and even possesses higher pharmacological properties. In this study, we have reported the synthesis and biological properties of quercetin functionalized biogenic silver nanoparticles (Qur-EA-AgNPs). AgNPs were synthesized using EA Leaf extract and functionalized with Quercetin. Qur-EA-AgNPs were characterized using various techniques and their biocompatibility was investigated. The UV-Visible spectrum of EA-AgNPs revealed a maximum absorbance at 428nm and quercetin functionalization results in a shift towards 390nm. The intense peak in the Fourier-transform infrared spectroscopy (FTIR) spectra revealed the quercetin functionalization on EA-AgNPs. Scanning electron microscope (SEM) results confirmed the spherical morphology of quercetin-functionalized AgNPs with a size range around 20nm which was further confirmed by High resolution transmission electron microscope (HRTEM). Energy Dispersive X-ray (EDX) spectrum evidenced the presence of Ag, C and O. Hemocompatibility of Qur-EA-AgNPs was confirmed from hemolytic assay showing <5% hemolysis. Moreover, Annexin V PI assay on Qur-EA-AgNPs treated peripheral blood mononuclear cells (PBMCs) showed 78.58 % viability significantly which is comparable with the control cells and its biocompatible nature was proved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据