4.4 Editorial Material

Hyperexcitability, neurodegeneration, and disease progression in amyotrophic lateral sclerosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Assessment of motor unit firing by high-density surface electromyography detects motor neuronal hyperexcitable state in amyotrophic lateral sclerosis

Yu-ichi Noto et al.

Summary: This study aimed to clarify the characteristics of motor unit (MU) firing rate and its association with clinical factors in amyotrophic lateral sclerosis (ALS) patients using high-density surface electromyography (HDSEMG) and MU decomposition analysis. Results showed that ALS patients had a higher MU firing rate during muscle contraction at a low force level, indicating a motor neuronal hyperexcitable state. The noninvasive assessment of MU firing rate by HDSEMG could provide a new evaluation method for ALS patients.

MUSCLE & NERVE (2023)

Article Clinical Neurology

Cortical inexcitability defines an adverse clinical profile in amyotrophic lateral sclerosis

T. Dharmadasa et al.

Summary: In amyotrophic lateral sclerosis, patients with inexcitability of all four limbs to transcranial magnetic stimulation have a distinct clinical profile characterized by younger age, lower-limb onset, faster disease progression, greater functional disability, and reduced survival. This measure may serve as an important prognostic marker in the disease.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

Review Clinical Neurology

Improving clinical trial outcomes in amyotrophic lateral sclerosis

Matthew C. Kiernan et al.

Summary: Researchers emphasize that a better understanding of the biological processes in amyotrophic lateral sclerosis has led to the identification of pathogenic targets and an increasing likelihood of effective therapies. Additionally, advancements in precision medicine and improved clinical trial designs will facilitate the acceleration of therapeutic approaches.

NATURE REVIEWS NEUROLOGY (2021)

Article Clinical Neurology

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis A Randomized Clinical Trial

Brian J. Wainger et al.

Summary: This study found that ezogabine can decrease cortical and spinal motor neuron excitability in patients with ALS, indicating the potential use of neurophysiological metrics as pharmacodynamic biomarkers in multi-site clinical trials.

JAMA NEUROLOGY (2021)

Editorial Material Clinical Neurology

A proposal for new diagnostic criteria for ALSY

Jeremy M. Shefner et al.

CLINICAL NEUROPHYSIOLOGY (2020)

Review Clinical Neurology

Axonal Excitability in Amyotrophic Lateral Sclerosis

Susanna B. Park et al.

NEUROTHERAPEUTICS (2017)

Review Clinical Neurology

Cortical influences drive amyotrophic lateral sclerosis

Andrew Eisen et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

Review Clinical Neurology

Quantifying Disease Progression in Amyotrophic Lateral Sclerosis

Neil G. Simon et al.

ANNALS OF NEUROLOGY (2014)

Article Medicine, General & Internal

Amyotrophic lateral sclerosis

Matthew C. Kiernan et al.

LANCET (2011)