相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease
Danna Jennings et al.
MOVEMENT DISORDERS (2023)
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
Enquan Xu et al.
MOLECULAR NEURODEGENERATION (2022)
Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk
Julie Lake et al.
MOVEMENT DISORDERS (2022)
Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease
Shijie Wang et al.
MOVEMENT DISORDERS (2022)
Impact of 100 LRRK2 variants linked to Parkinson’s Disease on kinase activity and microtubule binding
Alexia F Kalogeropulou et al.
BIOCHEMICAL JOURNAL (2022)
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease
Danna Jennings et al.
SCIENCE TRANSLATIONAL MEDICINE (2022)
Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort
Nicole Bryant et al.
HUMAN MOLECULAR GENETICS (2021)
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation
Malidi Ahamadi et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)
R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
Ying Fan et al.
ACTA NEUROPATHOLOGICA (2021)
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits
Marco A. S. Baptista et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans A Genome-Wide Association Study
Jia Nee Foo et al.
JAMA NEUROLOGY (2020)
Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients
Omar S. Mabrouk et al.
FRONTIERS IN NEUROSCIENCE (2020)
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics
Kaela Kelly et al.
FRONTIERS IN NEUROSCIENCE (2020)
Exosome markers of LRRK2 kinase inhibition
Shijie Wang et al.
NPJ PARKINSONS DISEASE (2020)
Caught in the act: LRRK2 in exosomes
Shijie Wang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls et al.
LANCET NEUROLOGY (2019)
Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval
Emily A. King et al.
PLOS GENETICS (2019)
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
Elena Kozina et al.
BRAIN (2018)
The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition
Kaela Kelly et al.
EXPERIMENTAL NEUROLOGY (2018)
Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease
Kyle B. Fraser et al.
MOVEMENT DISORDERS (2016)
Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers
Kyle B. Fraser et al.
NEUROLOGY (2016)
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Martin Steger et al.
ELIFE (2016)
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Reina N. Fuji et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease
Lorraine V. Kalia et al.
JAMA NEUROLOGY (2015)
Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic
Andrew B. West
MOVEMENT DISORDERS (2015)
Disease Penetrance of Late-Onset Parkinsonism A Meta-analysis
Joanne Trinh et al.
JAMA NEUROLOGY (2014)
LRRK2 secretion in exosomes is regulated by 14-3-3
Kyle B. Fraser et al.
HUMAN MOLECULAR GENETICS (2013)
Determining target engagement in living systems
Gabriel M. Simon et al.
NATURE CHEMICAL BIOLOGY (2013)
Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
Anthony A. Estrada et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Zejuan Sheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections
Roland Nau et al.
CLINICAL MICROBIOLOGY REVIEWS (2010)
Bridging the Valley of Death of therapeutics for neurodegeneration
Steven Finkbeiner
NATURE MEDICINE (2010)
Translational research: Crossing the valley of death
Declan Butler
NATURE (2008)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)