4.6 Article

A Double-Blind, Randomized, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

A pilot to assess target engagement of terazosin in Parkinson's disease

Jordan L. Schultz et al.

Summary: This 12-week pilot study in people with PD suggests that terazosin may engage its target and increase ATP levels in the brain and blood. However, mild dizziness/lightheadedness was more common in the terazosin group, leading to dropouts in some participants. Further studies are needed to explore the disease-modifying potential of terazosin.

PARKINSONISM & RELATED DISORDERS (2022)

Article Cell Biology

The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease

Brage Brakedal et al.

Summary: In this study, we found that oral intake of nicotinamide riboside (NR) in Parkinson's disease (PD) patients was safe and increased cerebral NAD levels, leading to altered cerebral metabolism and mild clinical improvement. NR also upregulated processes related to mitochondrial, lysosomal, and proteasomal function in blood cells and/or skeletal muscle, and decreased the levels of inflammatory cytokines.

CELL METABOLISM (2022)

Review Cell Biology

Fighting Parkinson's disease: The return of the mitochondria

Kevin Zambrano et al.

Summary: Parkinson's disease is a common neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the brain. Mitochondrial dysfunction, oxidative stress, and accumulation of alpha-synuclein contribute to the progression of PD. Recent evidence suggests that mitochondrial transfer/transplantation could be a potential therapeutic approach for PD.

MITOCHONDRION (2022)

Review Neurosciences

Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects

Max Borsche et al.

Summary: Mitochondrial dysfunction plays a critical role in the pathogenesis of Parkinson's disease, with genetic and idiopathic PD studies supporting its contribution. Some PD patients carry genetic alterations related to mitochondrial function, highlighting the importance of mitochondrial pathways in PD. Therefore, therapeutic approaches targeting mitochondrial dysfunction may hold potential in preventing or delaying neurodegeneration in PD.

JOURNAL OF PARKINSONS DISEASE (2021)

Article Neurosciences

Ursodeoxycholic acid protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis in MPTP/MPP+-induced Parkinson's disease

Huiping Qi et al.

Summary: Neuroprotection targeting mitochondrial dysfunction with ursodeoxycholic acid (UDCA) shows potential therapeutic effects for Parkinson's disease (PD). UDCA improves motor dysfunction, protects dopaminergic neurons, and regulates autophagy and apoptosis through activating the AMPK/mTOR and PINK1/Parkin pathways. The study suggests that UDCA may have pharmacological benefits in treating PD by modulating mitochondrial function.

NEUROSCIENCE LETTERS (2021)

Article Clinical Neurology

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease A Randomized Clinical Trial

Tanya Simuni et al.

Summary: This study aimed to evaluate the safety and tolerability of nilotinib in Parkinson disease patients, as well as its impact on various disease-related parameters. The results showed a negative trend in efficacy, low penetration of nilotinib in cerebrospinal fluid, and no alteration of dopamine metabolites levels, indicating that further testing of nilotinib for PD treatment is not recommended.

JAMA NEUROLOGY (2021)

Article Biochemistry & Molecular Biology

Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson's Disease

Peipei Li et al.

Summary: The gut microbiome can impact brain health and is altered in Parkinson's disease. The vermiform appendix, a lymphoid tissue in the cecum, is implicated in the storage and regulation of the gut microbiota. Changes in the appendix microbiome in PD patients include dysbiosis affecting lipid metabolism and an increase in toxic bile acids.

METABOLITES (2021)

Article Pharmacology & Pharmacy

Ursodeoxycholic Acid Treatment Restores Gut Microbiota and Alleviates Liver Inflammation in Non-Alcoholic Steatohepatitic Mouse Model

Hu Li et al.

Summary: Gut microbiota dysbiosis is closely related to the progression of NAFLD, and UDCA treatment can partially restore gut microbiota, repair gut barrier integrity, and attenuate hepatic inflammation in the NASH mouse model.

FRONTIERS IN PHARMACOLOGY (2021)

Article Geriatrics & Gerontology

Progressive Gait Deficits in Parkinson's Disease: A Wearable-Based Biannual 5-Year Prospective Study

Markus A. Hobert et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Clinical Neurology

Gait analysis with wearables predicts conversion to parkinson disease

Silvia Del Din et al.

ANNALS OF NEUROLOGY (2019)

Article Clinical Neurology

Step length predicts executive dysfunction in Parkinson's disease: a 3-year prospective study

Marianna Amboni et al.

JOURNAL OF NEUROLOGY (2018)

Article Neurosciences

Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease

Alexandra Isabel Rosa et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson's Disease

Stewart E. Graham et al.

METABOLITES (2018)

Review Clinical Neurology

Systematic Review of Levodopa Dose Equivalency Reporting in Parkinson's Disease

Claire L. Tomlinson et al.

MOVEMENT DISORDERS (2010)

Article Cell Biology

Multinuclear Magnetic Resonance Spectroscopy for in Vivo Assessment of Mitochondrial Dysfunction in Parkinson's Disease

Claire Henchcliffe et al.

MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)

Article Gastroenterology & Hepatology

High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective

Susan N. Cullen et al.

JOURNAL OF HEPATOLOGY (2008)

Article Geriatrics & Gerontology

The montreal cognitive assessment, MoCA:: A brief screening tool for mild cognitive impairment

ZS Nasreddine et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2005)

Article Biophysics

Estimation of gait cycle characteristics by trunk accelerometry

R Moe-Nilssen et al.

JOURNAL OF BIOMECHANICS (2004)

Review Gastroenterology & Hepatology

Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'

KN Lazaridis et al.

JOURNAL OF HEPATOLOGY (2001)