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Review
Biochemistry & Molecular Biology
Walhan Alshaer et al.
Summary: Nanomedicine is a growing field and liposomal formulations are a major platform in this field. Quality by design (QbD) is a powerful approach that can be applied to develop liposomal-based nano-pharmaceuticals, ensuring efficient and safe therapeutics. This review discusses the current practices of employing QbD in this area.
Article
Biochemistry & Molecular Biology
Wafa K. Fatani et al.
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide. Erlotinib, a tyrosine kinase inhibitor, has been explored as a potential treatment for lung cancer. Researchers have formulated two different generations of polyamidoamine (PAMAM) dendrimers and evaluated their efficacy in delivering erlotinib. The results showed that the cationic G4 dendrimer had higher selectivity and antiproliferative activity against lung cancer cells compared to the neutral G5 dendrimer and erlotinib alone, suggesting its potential as a targeted and sustained release carrier for erlotinib.
Article
Biochemistry & Molecular Biology
Sakchai Auychaipornlert et al.
Summary: Novel turmeric rhizome extract nanoparticles (TE-NPs) were successfully developed with high cytotoxicity and potential application in cancer therapy.
Article
Biochemistry & Molecular Biology
Fakhria A. Al-Joufi et al.
Summary: This study aimed to enhance ocular delivery of ciprofloxacin using liposomal drops in order to control post-surgical infections, particularly conjunctivitis and endogenous bacterial endophthalmitis. The prepared formulations showed promising results in terms of particle size, entrapment efficiency, antibacterial activity, and pharmacokinetics, outperforming commercial eye drops. The study concluded that the prepared ophthalmic formulations significantly improved ciprofloxacin bioavailability compared to the commercial product.
Review
Biochemistry & Molecular Biology
Madhuchandra Kenchegowda et al.
Summary: Nanocarrier-based systems are promising in cancer treatment by selectively responding to cancer-specific conditions and efficiently delivering drugs to target cells. This review provides a comprehensive discussion on recent advances in smart nanocarriers.
Article
Biochemistry & Molecular Biology
Dorina Gabriella Dobo et al.
Summary: This study aimed to produce thermosensitive liposomes using the quality by design concept and investigated the parameters affecting the quality of the liposomal product. The findings showed that the thermal properties of liposomes are influenced by the types and ratios of lipids used.
Article
Biochemistry & Molecular Biology
Amarjitsing Rajput et al.
Summary: This study developed a levonorgestrel liposome-loaded microneedle array patch for contraception, which showed better efficacy than the drug-loaded microneedle array patch. The sustained release behavior of levonorgestrel was observed for 28 days.
Article
Biochemistry & Molecular Biology
Ahad S. Abushal et al.
Summary: Psoriatic arthritis is an autoimmune disease that causes joint inflammation and damage. The current treatments are limited in effectiveness and convenience. A study found that a self-nanoemulsifying drug delivery system (SNEDDS) improved the solubility and bioavailability of the medication Apremilast. The optimized formulation, F9, showed the highest drug release in vitro and further investigation is needed for its potential as an alternative delivery system.
Article
Biochemistry & Molecular Biology
Mohd Abul Kalam et al.
Summary: This study developed topically applied chitosan-nanoparticles for delivering tedizolid phosphate to treat MRSA-related ocular infections. The nanoparticles showed good drug encapsulation and sustained release properties. They effectively inhibited the growth of Gram-positive bacteria and demonstrated improved corneal retention compared to the aqueous suspension. No irritation was observed in rabbit eyes. These findings suggest the potential of the nanoparticles for treating ocular MRSA infections.
Review
Biochemistry & Molecular Biology
Rajeev Kumar et al.
Summary: Oral diseases pose a major global threat to public health, and natural products may be a key approach to prevention and treatment. However, the field faces challenges due to physicochemical and pharmacokinetic properties. Nanotechnology could play a crucial role in enhancing the safety and efficacy of natural products.
Article
Biochemistry & Molecular Biology
Abdullah Alshememry et al.
Summary: This study aimed to improve the utilization of positively charged nanocrystals (NCs) of Tedizolid Phosphate (TZP) for ocular applications. The study found that the NC1 nanocrystals showed better antibacterial activity and pharmokinetic properties compared to the traditional TZP solution, suggesting its potential as a substitute for ocular drug delivery.
Article
Biochemistry & Molecular Biology
Aleksandra Nurzynska et al.
Summary: This study developed a novel fullerene derivative, C-60 fullerenol-gentamicin conjugate, and demonstrated its antibacterial activity and lack of cytotoxicity. The research presents an effective method for utilizing fullerenol as a carrier for antibiotics, and suggests the potential biomedical applications of the derived conjugate.
Article
Biochemistry & Molecular Biology
Faiyaz Shakeel et al.
Summary: The study aimed to improve the oral bioavailability of the natural pharmaceutical compound luteolin (LUT) by creating self-nanoemulsifying drug delivery systems (SNEDDS). The findings suggested that SNEDDS could enhance the dissolution rate and therapeutic efficacy of bioflavonoid LUT.
