期刊
MOLECULES
卷 28, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules28124751
关键词
green chemistry; photochemistry; visible-light photocatalysis; [3+2] cycloaddition; naphtho[2; 3-b]furan-4; 9-diones; dihydronaphtho[2
A visible-light-mediated [3+2] cycloaddition reaction has been developed for the synthesis of important naphtho[2,3-b]furan-4,9-dione compounds. This new method offers a powerful, green, efficient, and facile means to expand the structural diversity of these compounds as promising scaffolds for novel drug discovery. It demonstrates excellent regioselectivity and remarkable functional group tolerance, delivering a variety of target compounds in good yields under environmentally friendly conditions.
Naphtho[2,3-b]furan-4,9-dione is an important privileged structural motif which is present in natural products, drugs, and drug candidates. Herein, visible-light-mediated [3+2] cycloaddition reaction for the synthesis of naphtho[2,3-b]furan-4,9-diones and dihydronaphtho[2,3-b]furan-4,9-diones has been developed. Under environmentally friendly conditions, a variety of title compounds were delivered in good yields. This new protocol shows excellent regioselectivity and remarkable functional group tolerance. This approach provides a powerful, green, efficient, and facile means to expand the structural diversity of naphtho[2,3-b]furan-4,9-diones and dihydronaph-tho[2,3-b]furan-4,9-diones as promising scaffolds for novel drug discovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据