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Towards More Practical Methods for the Chemical Synthesis of Thioamides Using Sulfuration Agents: A Decade Update

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MOLECULES
卷 28, 期 8, 页码 -

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MDPI
DOI: 10.3390/molecules28083527

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thioamide; sulfur; sulfuration agent

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Compounds with thioamide function are important in organic synthesis as key building blocks and in drug design due to their ability to mimic amide function in biomolecules. This review provides an update on the last decade's contributions in the formation of thioamides using different sulfur sources, highlighting the cleanliness and practicality of the new methods.
Compounds possessing a thioamide function play a crucial role in organic synthesis, serving as key building blocks. They are also important in the pharmaceutical chemistry and drug design, owing to their ability to mimic the amide function in biomolecules while retaining or developing biological activity. From the synthetic viewpoint, several methods have been developed for preparing thioamides using sulfuration agents. The purpose of this review is to give an update of the last decade of contributions focusing on the formation of thioamides employing different sulfur sources. When appropriate, the cleanness and practicality of the new methods are highlighted.

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