4.6 Article

The Efficient Synthesis and Anti-Fatigue Activity Evaluation of Macamides: The Unique Bioactive Compounds in Maca

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MOLECULES
卷 28, 期 9, 页码 -

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MDPI
DOI: 10.3390/molecules28093943

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macamides; bioactive marker compounds; synthesis; carbodiimide condensation method; anti-fatigue

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Macamides are unique to maca and are considered to be its bioactive compounds. A total of thirty macamide monomers have been identified, but obtaining a single macamide monomer from maca is challenging due to their similar structures. In this study, we successfully synthesized and purified five typical macamides using the carbodiimide condensation method. The most abundant macamide monomer in maca, N-benzyl-hexadecanamide (NBH), was found to enhance endurance capacity and reduce fatigue-related markers in mice. Macamides potentially contribute to maca's anti-fatigue effects.
Macamides are a class of amide alkaloids that are only found in maca and are widely considered to be its bioactive marker compounds. More than thirty macamide monomers have been identified in recent years; however, it is difficult to obtain a single macamide monomer from the maca plant because of their similar structures and characteristics. We used the carbodiimide condensation method (CCM) to efficiently synthesize five typical macamides, including N-benzyl-hexadecanamide (NBH), N-benzyl-9Z,12Z,15Z-octadecenamide, N-(3-methoxybenzyl)-9Z,12Z-octadecenamide, N-benzyl-9Z,12Z-octadecenamide, and N-(3-methoxybenzyl)-9Z,12Z,15Z-octadecadienamide. All the synthesized macamides were purified by a one-step HPLC with a purity of more than 95%. NBH is the most abundant macamide monomer in natural maca, and it was selected to evaluate the anti-fatigue effects of macamides. The results indicated that NBH could enhance the endurance capacity of mice by increasing liver glycogen levels and decreasing blood urea nitrogen, lactate dehydrogenase, blood ammonia, and blood lactic acid levels. Macamides might be the active substances that give maca its anti-fatigue active function.

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