XDH and XO Research and Drug Discovery-Personal History

The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of this conversion was elucidated in this study. The physiological and pathological significance of this conversion is presented. Finally, enzyme inhibitors were successfully developed, two of which are used as therapeutic agents for gout. Their wide application potential is also discussed.

Automated summary

The author provides an overview of the research history on the main issues discussed in the paper, and highlights their personal involvement in the research. XDH, responsible for purine degradation, is found in various organisms, while conversion to XO only occurs in mammals. This study elucidates the molecular mechanism of this conversion and presents its physiological and pathological significance. Additionally, enzyme inhibitors have been successfully developed, with two being used as therapeutic agents for gout, and their potential for wide application is discussed.