4.6 Review

Possible Side Effects of Polyphenols and Their Interactions with Medicines

期刊

MOLECULES
卷 28, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/molecules28062536

关键词

polyphenols; side effect; prooxidant activity; toxicity; mutations; DNA damage; drug interactions; cytochrome P450

向作者/读者索取更多资源

Polyphenols are important components of plant-derived food that have a wide range of beneficial effects on human health. However, they can also have harmful effects, such as blocking iron uptake, inhibiting digestive enzymes, disrupting intestinal microbiota, interacting with drugs, and affecting hormonal balance. Public awareness needs to be raised on the potential side effects of polyphenol supplementation, especially for vulnerable populations.
Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols' ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据