DNA-Guided Metallization of Nanomaterials and Their Biomedical Applications

Precise control of the structure of metallic nanomaterials is critical for the advancement of nanobiotechnology. As DNA (deoxyribonucleic acid) can readily modify various moieties, such as sulfhydryl, carboxyl, and amino groups, using DNA as a directing ligand to modulate the morphology of nanomaterials is a promising strategy. In this review, we focus on the use of DNA as a template to control the morphology of metallic nanoparticles and their biomedical applications, discuss the use of DNA for the metallization of gold and silver, explore the factors that influence the process, and outline its biomedical applications. This review aims to provide valuable insights into the DNA-guided growth of nanomaterials. The challenges and future directions are also discussed.

Automated summary

Precise control of metallic nanomaterials structure is crucial for nanobiotechnology. DNA as a directing ligand to modulate nanomaterial morphology is a promising strategy. This review focuses on the use of DNA as a template to control metallic nanoparticles morphology and their biomedical applications, discusses the metallization of gold and silver using DNA, explores influencing factors, and outlines its biomedical applications. The aim is to provide insights into DNA-guided growth of nanomaterials and discuss challenges and future directions.