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注意：仅列出部分参考文献，下载原文获取全部文献信息。Fragment-to-Lead Medicinal Chemistry Publications in 2020
Iwan J. P. de Esch et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries
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DRUG DISCOVERY TODAY (2022)
Simple and modestly scalable synthesis of iso-Cyrene from levoglucosenone and its comparison to the bio-derived and polar aprotic solvent Cyrene®
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AUSTRALIAN JOURNAL OF CHEMISTRY (2022)
Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction
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POLYMERS (2022)
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MOLECULAR ONCOLOGY (2022)
The Time and Place for Nature in Drug Discovery
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JACS AU (2022)
Reactivity, Selectivity, and Synthesis of 4-C-Silylated Glycosyl Donors and 4-Deoxy Analogues
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Escape from planarity in fragment-based drug discovery: A physicochemical and 3D property analysis of synthetic 3D fragment libraries
David J. Hamilton et al.
Drug Discovery Today: Technologies (2021)
Application of sulfoximines in medicinal chemistry from 2013 to 2020
Yu Han et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
From recipe to research: introducing undergraduate students to the nature o science using a hybrid practical course centred on drug discovery for neglected diseases
Maikel Wijtmans et al.
DRUG DISCOVERY TODAY (2021)
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design
Yong-Jin Wu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
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CHEMICAL SOCIETY REVIEWS (2021)
C-H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD)
Gianni Chessari et al.
CHEMICAL SCIENCE (2021)
Natural product-informed exploration of chemical space to enable bioactive molecular discovery
Adam Nelson et al.
RSC MEDICINAL CHEMISTRY (2021)
Design and Synthesis of 56 Shape-Diverse 3D Fragments
Thomas D. Downes et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
Generation Green - A holistic approach to implementation of green principles and practices in educational programmes in pharmaceutical and medical sciences at the University of Helsinki
Mia Siven et al.
SUSTAINABLE CHEMISTRY AND PHARMACY (2020)
Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry
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JOURNAL OF MEDICINAL CHEMISTRY (2020)
A Review of Recent Advances in Biomass Pyrolysis
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ENERGY & FUELS (2020)
Levoglucosan: a promising platform molecule?
Ivaldo Itabaiana et al.
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A review on pyrolysis of protein-rich biomass: Nitrogen transformation
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BIORESOURCE TECHNOLOGY (2020)
Synthesis and fungicidal activity of methylsulfanylmethyl ether derivatives of levoglucosenone
Bulat T. Sharipov et al.
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Fragment Hits: What do They Look Like and How do They Bind?
Fabrizio Giordanetto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Sustainable Biomass Materials for Biomedical Applications
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ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)
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Lei Zhang et al.
CURRENT MEDICINAL CHEMISTRY (2019)
Fragment-based screening with natural products for novel anti-parasitic disease drug discovery
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EXPERT OPINION ON DRUG DISCOVERY (2019)
A review on biomass: importance, chemistry, classification, and conversion
Antonio Tursi
BIOFUEL RESEARCH JOURNAL-BRJ (2019)
Development of pharmaceutically relevant bio-based intermediates though aldol condensation and Claisen-Schmidt reactions of dihydrolevoglucosenone (Cyrene (R))
Liam Hughes et al.
GREEN CHEMISTRY (2018)
Organic solvent- and catalyst-free Baeyer-Villiger oxidation of levoglucosenone and dihydrolevoglucosenone (Cyrene (R)): a sustainable route to (S)-gamma-hydroxymethyl-alpha,beta-butenolide and (S)-gamma-hydroxymethyl-gamma-butyrolactone
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GREEN CHEMISTRY (2018)
Synthesis of a Chiral Auxiliary Family from Levoglucosenone and Evaluation in the Diels-Alder Reaction
Julian Klepp et al.
SYNLETT (2018)
Bio-available Solvent Cyrene: Synthesis, Derivatization, and Applications
Jason E. Camp
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Current perspectives in fragment-based lead discovery (FBLD)
Bas Lamoree et al.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
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Exploring Natural Product Fragments for Drug and Probe Discovery
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BIOORGANIC & MEDICINAL CHEMISTRY (2017)
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BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2016)
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DRUG DISCOVERY TODAY (2016)
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Dihydrolevoglucosenone (Cyrene) As a Green Alternative to N,N-Dimethylformamide (DMF) in MOF Synthesis
Jinfeng Zhang et al.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2016)
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CHEMICAL COMMUNICATIONS (2014)
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Zoya Titarenko et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Natural-product-derived fragments for fragment-based ligand discovery
Bjoern Over et al.
NATURE CHEMISTRY (2013)
The 'rule of three' for fragment-based drug discovery: where are we now?
Harren Jhoti et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Plane of Best Fit: A Novel Method to Characterize the Three-Dimensionality of Molecules
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JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Molecular complexity and fragment-based drug discovery: ten years on
Andrew R. Leach et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2011)
Comparison of Nephelometric, UV-Spectroscopic, and HPLC Methods for High-Throughput Determination of Aqueous Drug Solubility in Microtiter Plates
Bettina Hoelke et al.
ANALYTICAL CHEMISTRY (2009)
Quantifying biogenic bias in screening libraries
Jerome Hert et al.
NATURE CHEMICAL BIOLOGY (2009)
Synthesis of 2-amino derivatives of levoglucosenone
FA Valeev et al.
CHEMISTRY OF NATURAL COMPOUNDS (2004)
Stereochemical aspects of the Beckman rearrangement of oximes of levoglucosenone and its dihydro derivative. Enantioselective synthesis of (+)-gamma-pelargonolactone
FA Valeev et al.
CHEMISTRY OF NATURAL COMPOUNDS (2003)
Molecular complexity and its impact on the probability of finding leads for drug discovery
MM Hann et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2001)
Improving science teachers' conceptions of nature of science: a critical review of the literature
F Abd-El-Khalick et al.
INTERNATIONAL JOURNAL OF SCIENCE EDUCATION (2000)
A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates
CD Bevan et al.
ANALYTICAL CHEMISTRY (2000)
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