期刊
MOLECULES
卷 28, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules28124774
关键词
prothioconazole; toxicity effects; Scenedesmus obliquus; enantioselectivity
The enantioselective toxic effects of Prothioconazole (PTC) on Scendesmus obliquus (S. obliquus) were investigated. It was found that R-(-)-PTC had less impact on the growth and photosynthetic pigment contents of S. obliquus compared to Rac-PTC and S-(+)-PTC. This study provides important information for the ecological risk assessment of PTC.
Prothioconazole (PTC) is a broad-spectrum triazole fungicide with one asymmetric center and consists of two enantiomers, R-(-)-PTC and S-(+)-PTC. To address the concern of its environmental safety, the enantioselective toxic effects of PTC on Scendesmus obliquus (S. obliquus) were investigated. PTC racemates (Rac-PTC) and enantiomers exhibited dose-dependent acute toxicity effects against S. obliquus at a concentration from 1 to 10 mg & BULL;L-1. The 72 h-EC50 value of Rac-, R-(-)-, and S-(+)-PTC is 8.15, 16.53, and 7.85 mg & BULL;L-1, respectively. The growth ratios and photosynthetic pigment contents of the R-(-)-PTC treatment groups were higher than the Rac- and S-(+)-PTC treatment groups. Both catalase (CAT) activities and esterase activities were inhibited in the Rac- and S-(+)-PTC treatment groups at high concentrations of 5 and 10 mg & BULL;L-1, and the levels of malondialdehyde (MDA) were elevated, which exceeded the levels in algal cells for the R-(-)-PTC treatment groups. PTC could disrupt the cell morphology of S. obliquus and induce cell membrane damage, following the order of S-(+)-PTC & AP; Rac-PTC > R-(-)-PTC. The enantioselective toxic effects of PTC on S. obliquus provide essential information for its ecological risk assessment.
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