☆ 4.6 Article

Novel Effect of p-Coumaric Acid on Hepatic Lipolysis: Inhibition of Hepatic Lipid-Droplets

MOLECULES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Attenuation of hepatic fibrosis by p -Coumaric acid via modulation of NLRP3 inflammasome activation in C57BL/6 mice

Thi My Tien Truong et al.

Summary: A prolonged HFHS diet induces hepatic inflammation and mediates HSC activation, resulting in hepatic fibrosis. PCA-enriched peanut sprout extracts can reduce hepatic fibrosis by modulating innate immunity and HSC activation, and have anti-inflammatory effects.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2023)

添加到收藏夹

Review Medicine, Research & Experimental

Steatosis in metabolic diseases: A focus on lipolysis and lipophagy

Xingtao Zhao et al.

Summary: This review focuses on the effects of lipolytic enzymes on lipid metabolism homeostasis and energy conservation, as well as their role in lipid-related metabolic diseases. It also explores the impact of these enzymes on hepatic steatosis and cancer through immune inflammation, oxidative stress, and autophagy-related pathways. Additionally, it examines the current application of lipolytic enzyme inhibitors, especially Monoacylglycerol lipase (MGL) inhibitors, as potential strategies for future exploration of metabolic programming in metabolic diseases.

BIOMEDICINE & PHARMACOTHERAPY (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Benefits of p-coumaric acid in mice with rotenone-induced neurodegeneration

Nurinee Dolrahman et al.

Summary: This paper examines the use of natural antioxidant and anti-inflammation substances as potential therapeutic candidates for brain disease, specifically focusing on the phenolic compound pCA. The study investigates the effects of pCA on rotenone-induced Parkinson's disease-like pathology in mice. Results show that pCA has a neuroprotective effect, reducing oxidative damage and inflammation, inhibiting neurodegeneration, and improving tyrosine hydroxylase levels in the substantia nigra par compacta and striatum, thereby alleviating motor deficits.

METABOLIC BRAIN DISEASE (2023)

添加到收藏夹

Article Microbiology

Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway

Xifen Zheng et al.

Summary: Intestinal bacterial strain Akkermansia muciniphila plays a role in improving carbohydrate and lipid metabolism, alleviating obesity symptoms. The membrane protein Amuc_1100 of Akk regulates lipid metabolism in 3T3-L1 preadipocytes. Understanding the specific molecules and functional mechanisms of Akk may lead to new therapeutic approaches for obesity.

MICROBIOLOGY SPECTRUM (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet obese C57BL/6 mice

Golnaz Goodarzi et al.

Summary: The combination therapy of metformin (MET) and p-coumaric acid (PCA) effectively improves weight gain, fat deposition, liver inflammation, and induces thermogenesis and adipose tissue browning in a high-fat diet-induced NAFLD mouse model.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

microRNA-27b regulates hepatic lipase enzyme LIPC and reduces triglyceride degradation during hepatitis C virus infection

Genevieve F. Desrochers et al.

Summary: miR-27b plays a crucial role in regulating HCV infection by modulating the balance of lipid pathway through targeting LIPC.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease

Anja Baumann et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferulic Acid and P-Coumaric Acid Synergistically Attenuate Non-Alcoholic Fatty Liver Disease through HDAC1/PPARG-Mediated Free Fatty Acid Uptake

Kaili Cui et al.

Summary: This study investigated the mechanism underlying the impact of ferulic acid and p-coumaric acid on non-alcoholic fatty liver disease (NAFLD). The results suggested that these acids improve NAFLD by inhibiting free fatty acid uptake and may serve as potential dietary supplements and drugs for preventing NAFLD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC

Rui Wang et al.

Summary: The findings suggest that WY-14,643 inhibits the malignant behaviors of ccRCC by modulating lipid metabolism and targeting the PPAR alpha/CPT1A axis.

LIPIDS IN HEALTH AND DISEASE (2022)

添加到收藏夹

Article

An Overview of Hormone-Sensitive Lipase (HSL)

Arwa R. Althaher

TheScientificWorldJOURNAL (2022)

添加到收藏夹

Review Medicine, General & Internal

Current treatment of non-alcoholic fatty liver disease

Rafael Paternostro et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease with various pathologies. In addition to lifestyle changes and a few specific medications, there are new treatment options being studied. Treating complications of end-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is important for the treatment of the complete clinical spectrum of NAFLD.

JOURNAL OF INTERNAL MEDICINE (2022)

添加到收藏夹

Article Immunology

p-Coumaric acid ameliorates cognitive and non-cognitive disturbances in a rat model of Alzheimer?s disease: The role of oxidative stress and inflammation

Shahab Ghaderi et al.

Summary: This study investigated the effects of p-coumaric acid (p-CA) on cognitive and non-cognitive deficits in an Alzheimer's disease (AD) rat model induced by aluminum chloride (AlCl3). The results showed that p-CA treatment alleviated anxiety/depression-like behaviors, improved locomotor/exploratory activities, and enhanced spatial learning and memory. These beneficial effects may be attributed to the anti-oxidative and anti-inflammatory properties of p-CA.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Food Science & Technology

Deciphering the antibacterial activity and mechanism of p-coumaric acid against Alicyclobacillus acidoterrestris and its application in apple juice

Jun Li et al.

Summary: This study investigated the antibacterial activity and mechanism of p-coumaric acid against Alicyclobacillus acidoterrestris and its application in apple juice. The results showed that p-coumaric acid had inhibitory effects on both vegetative cells and spores of A. acidoterrestris, damaging cell integrity and disrupting cellular functions. Furthermore, the addition of p-coumaric acid effectively reduced the growth of A. acidoterrestris in apple juice.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis

Kaili Cui et al.

Summary: Polyphenol-rich foods, such as foxtail millet, have potential beneficial effects in the prevention and treatment of cancer. Ferulic acid and p-coumaric acid, found in foxtail millet bran, exhibit significant anticancer properties and have a synergistic effect. These compounds inhibit aerobic glycolysis of colorectal cancer cells by targeting lncRNA 495810 and the rate-limiting enzyme PKM2.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

LIPC variant in combined hypocholesterolaemia

[Anonymous]

NATURE REVIEWS CARDIOLOGY (2022)

添加到收藏夹

Article Plant Sciences

Baccharin and p-coumaric acid from green propolis mitigate inflammation by modulating the production of cytokines and eicosanoikds

Juliana C. Ferreira et al.

Summary: The compounds Bac and pCA from Baccharis dracunculifolia D.C. were found to inhibit cellular infiltration and oxidative stress induced by inflammation, with regulatory effects on the production of inflammatory mediators.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

PKA and AMPK Signaling Pathways Differentially Regulate Luteal Steroidogenesis

Emilia Przygrodzka et al.

Summary: Luteinizing hormone (LH) regulates ovulation and formation of the corpus luteum, while AMP-activated protein kinase (AMPK) exerts inhibitory effects on steroidogenesis in luteal cells by modulating the actions of PKA. AMPK regulates cholesterol availability for steroidogenesis by mediating phosphorylation of hormone-sensitive lipase (HSL), in contrast to the phosphorylation effects of LH/PKA on HSL.

ENDOCRINOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

p-Coumaric Acid Enhances Hypothalamic Leptin Signaling and Glucose Homeostasis in Mice via Differential Effects on AMPK Activation

Linh V. Nguyen et al.

Summary: p-Coumaric acid potentially activates peripheral AMPK and improves glucose metabolism, while showing inhibitory effects on central AMPK activity. This differential effect enhances hypothalamic leptin sensitivity and improves whole-body glucose homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Medicine, General & Internal

Non-alcoholic fatty liver disease

Elizabeth E. Powell et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.

LANCET (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Thiazolidinediones and Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study

Judith van Dalem et al.

Summary: The study found that patients prescribed TZDs had a lower risk of NAFLD, while there was no significant difference in NAFLD risk between GLP-1 receptor agonist use and insulin use.

HEPATOLOGY (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

PPAR control of metabolism and cardiovascular functions

David Montaigne et al.

Summary: Novel PPAR agonists offer new opportunities for managing metabolic and cardiovascular diseases by regulating gene expression, lipid metabolism, insulin sensitivity, glucose metabolism, and cardiovascular health. Activation of PPARs by specific ligands can have antiatherogenic, anti-inflammatory, and metabolic benefits, making them important therapeutic targets in the treatment of various diseases.

NATURE REVIEWS CARDIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates

Peter Hoboth et al.

Summary: Using Single molecule localization microscopy (SMLM), this study presents a method for quantitative evaluation of nuclear PIPs distribution while preserving nuclear architecture background. By implementing dual-color dSTORM imaging and Nearest Neighbor Distance analysis, successful quantification and visualization of nuclear PIP2 were achieved.

METHODSX (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo

Chen Liang et al.

PHARMACOLOGICAL RESEARCH (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression

Raghad Khalid AL-Ishaq et al.

BIOMOLECULES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

Yaping Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis

Tianpeng Zhang et al.

THERANOSTICS (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation

Yingbin Shen et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

Matteo Tardelli et al.

JOURNAL OF LIPID RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

p-Coumaric acid inhibits the Listeria monocytogenes RecA protein functions and SOS response: An antimicrobial target

Debika Ojha et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

添加到收藏夹

Article Nutrition & Dietetics

Hepatic PKA inhibition accelerates the lipid accumulation in liver

Jining Yang et al.

NUTRITION & METABOLISM (2019)

添加到收藏夹

Article Medicine, Legal

Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate

Rihab Khlifi et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)

添加到收藏夹

Article Integrative & Complementary Medicine

p-Coumaric-Acid-Containing Adenostemma lavenia Ameliorates Acute Lung Injury by Activating AMPK/Nrf2/HO-1 Signaling and Improving the Anti-oxidant Response

Jian-Jung Chen et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2019)

添加到收藏夹

Article Cell Biology

Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription

Margarita Sobol et al.

JOURNAL OF CELL SCIENCE (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis

Taiyi Kuo et al.

DIABETES (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2: In vivo approach

Venkatesan Amalan et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Dietary Phenolic Acids of Macrotyloma uniflorum (Horse Gram) Protect the Rat Heart Against Isoproterenol-Induced Myocardial Infarction

Vandana Panda et al.

PHYTOTHERAPY RESEARCH (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

A functional variant in the exon 5 of PLIN1 reduces risk of central obesity by possible regulation of lipid storage

Weihua Song et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

添加到收藏夹

Editorial Material Medicine, Research & Experimental

FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis

Rudolf Zechner

EMBO MOLECULAR MEDICINE (2015)

添加到收藏夹

Article Cell Biology

Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

Lizhen Wu et al.

DEVELOPMENTAL CELL (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Perilipin discerns chronic from acute hepatocellular steatosis

Lena Maria Pawella et al.

JOURNAL OF HEPATOLOGY (2014)

添加到收藏夹

Review Endocrinology & Metabolism

Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD

Claudia D. Fuchs et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

p-Coumaric acid modulates glucose and lipid metabolism via AMP-activated protein kinase in L6 skeletal muscle cells

Seon-A Yoon et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

添加到收藏夹

Review Nutrition & Dietetics

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

Melania Gaggini et al.

NUTRIENTS (2013)

添加到收藏夹

Review Oncology

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention

Jeffrey M. Peters et al.

NATURE REVIEWS CANCER (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

Maryam Rakhshandehroo et al.

PLOS ONE (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of peroxisome-proliferator responsive element in the mouse HSL gene

Hiroaki Yajima et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

添加到收藏夹

Article Endocrinology & Metabolism

PPARγ agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control

W. T. Festuccia et al.

DIABETOLOGIA (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339

JS Millar et al.

JOURNAL OF LIPID RESEARCH (2005)

添加到收藏夹

Review Biochemistry & Molecular Biology

Metabolism and signaling activities of nuclear lipids

AM Martelli et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.