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Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action

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Summary: The peri- and post-menopausal periods are considered a vulnerable stage for women to develop depressive symptoms. The underlying mechanisms of these symptoms are multifactorial and may make traditional antidepressants less effective. In this study, the perturbation of the Nrf2 signaling pathway was investigated as a potential mechanism for post-ovariectomy depression, and the benefits of carnosic acid (CA) were highlighted. The results showed that CA could alleviate depressive behavior, improve neurobiochemical markers, reduce oxidative stress and inflammation, and protect against histopathological changes. This suggests that CA may be a promising candidate for clinical evaluation as an antidepressant.

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