期刊
MOLECULES
卷 28, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules28124736
关键词
capsaicin; EEG; TRPV1; brain rhythms; thermoregulation
The presence of TRPV1 ion channels in brain regions other than the hypothalamus has been debated. By injecting capsaicin directly into the lateral ventricle of rats and recording EEGs, we found that capsaicin perturbed brain electrical activity during sleep, suggesting TRPV1 expression in specific brain regions dominant during this stage.
The heat and capsaicin sensor TRPV1 ion channels were originally discovered in sensory neurons of dorsal root ganglia, and later found in many other tissues and organs. However, whether TRPV1 channels are present in brain regions other than the hypothalamus has been a subject of debate. Here, we addressed this issue with an unbiased functional test by recording electroencephalograms (EEGs) to examine whether capsaicin injection directly into the rat lateral ventricle could alter brain electrical activity. We observed that EEGs during the sleep stage could be significantly perturbed by capsaicin, whereas EEGs during the awake stage did not show a detectable change. Our results are consistent with TRPV1 expression in selective brain regions whose activities are dominative during the sleep stage.
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