期刊
MOLECULAR PHARMACEUTICS
卷 20, 期 6, 页码 3049-3059出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.3c00069
关键词
verticillin A; natural products; high-grade serous ovarian cancer; drug formulation; tolerability; xenograft
Verticillins, isolated from a fungus, show nanomolar anti-tumor activity in high-grade serous ovarian cancer. They significantly reduce tumor burden and induce apoptosis, but liver toxicity is observed in some cases.
Verticillins are epipolythiodioxopiperazine alkaloids isolated from a fungus with nanomolar anti-tumor activity in high-grade serous ovarian cancer (HGSOC). HGSOC is the fifth leading cause of death in women, and natural products continue to be an inspiration for new drug entities to help tackle chemoresistance. Verticillin D was recently found in a new fungal strain and compared to verticillin A. Both compounds exhibited nanomolar cytotoxic activity against OVCAR4 and OVCAR8 HGSOC cell lines, significantly reduced 2D foci and 3D spheroids, and induced apoptosis. In addition, verticillin A and verticillin D reduced tumor burden in vivo using OVCAR8 xenografts in the peritoneal space as a model. Unfortunately, mice treated with verticillin D displayed signs of liver toxicity. Tolerability studies to optimize verticillin A formulation for in vivo delivery were performed and compared to a semi-synthetic succinate version of verticillin A to monitor bioavailability in athymic nude females. Formulation of verticillins achieved tolerable drug delivery. Thus, formulation studies are effective at improving tolerability and demonstrating efficacy for verticillins.
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