期刊
MOLECULAR ONCOLOGY
卷 17, 期 5, 页码 737-746出版社
WILEY
DOI: 10.1002/1878-0261.13415
关键词
CTCs; cytology imprints; NSCLC; PD-L1
类别
Alternative sources of tumour information, such as cytology imprints and circulating tumour cells (CTCs), can be explored in NSCLC patients. This study compared the expression of PD-L1 on cytology imprints and CTCs to PD-L1 tumour proportion score (TPS) from immunohistochemistry staining of tumour tissue. The combination of cytological imprints and CTCs provides valuable information on the tumoural PD-L1 status in NSCLC patients when tumour tissue is not available.
Alternative sources of tumour information need to be explored in patients with non-small cell lung cancer (NSCLC). Here, we compared programmed cell death ligand 1 (PD-L1) expression on cytology imprints and circulating tumour cells (CTCs) with PD-L1 tumour proportion score (TPS) from immunohistochemistry staining of tumour tissue from patients with NSCLC. We evaluated PD-L1 expression using a PD-L1 antibody (28-8) in representative cytology imprints, and tissue samples from the same tumour. We report good agreement rates on PD-L1 positivity (TPS >= 1%) and high PD-L1 expression (TPS >= 50%). Considering high PD-L1 expression, cytology imprints showed a PPV of 64% and a NPV of 85%. CTCs were detected in 40% of the patients and 80% of them were PD-L1(+). Seven patients with PD-L1 expression of < 1% in tissue samples or cytology imprints had PD-L1(+) CTCs. The addition of PD-L1 expression in CTCs to cytology imprints markedly improved the prediction capacity for PD-L1 positivity. A combined analysis of cytological imprints and CTCs provides information on the tumoural PD-L1 status in NSCLC patients, which might be used when no tumor tissue is available.
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