☆ 4.7 Article

Oleanolic Acid Inhibits SCD1 Gene Expression to Ameliorate Fructose-Induced Hepatosteatosis through SREBP1c-Dependent and -Independent Mechanisms

MOLECULAR NUTRITION & FOOD RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD

Mustafa Kutlu Inci et al.

Summary: Increased fructose intake, especially in combination with a high-fat diet, can lead to obesity and metabolic complications. Fructose impairs the oxidation of dietary fat by affecting the mitochondrial beta-oxidation pathway and inhibiting the production of acylcarnitine. This explains the synergistic effects of fructose and fat on the development of conditions like non-alcoholic fatty liver disease.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2023)

添加到收藏夹

Article Plant Sciences

NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury

Jianming Liu et al.

Summary: This study found that the effect of oleanolic acid (OA) on cholestatic liver injury is closely related to the simultaneous activation of NRF2 and FXR dual signaling pathways, in which the NRF2 signaling pathway plays a more important role. The dual signaling pathways cooperatively regulate bile acid metabolic homeostasis through the interaction mechanism with β-catenin/P300.

PHYTOMEDICINE (2023)

添加到收藏夹

Article Respiratory System

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts

Zili Zhou et al.

Summary: This study found that lung fibroblast activation is associated with airway remodeling during asthma progression. In a mouse asthma model, the inhibition of SCD1 significantly improved airway remodeling and lung fibroblast activation. The study also found that the PI3K-Akt-mTOR-SREBP1 pathway is involved in the regulation of SCD1 expression and lung fibroblast activation. Therefore, the inhibition of SCD1 may be a therapeutic strategy for airway remodeling in asthma.

RESPIRATORY RESEARCH (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The effect of simvastatin on gene expression of low-density lipoprotein receptor, sterol regulatory element-binding proteins, stearoyl-CoA desaturase 1 mRNA in rat hepatic tissues

Abbas Nezhadebrahimi et al.

Summary: This study assessed the effect of simvastatin on gene expression in rat hepatic tissues fed with high-fat diets and its association with biochemical parameters.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

添加到收藏夹

Article Toxicology

Farnesoid X receptor contributes to oleanolic acid-induced cholestatic liver injury in mice

Hong Feng et al.

Summary: Knockout of FXR can alleviate OA-induced cholestatic liver injury in mice by reducing bile acid accumulation in the liver and serum, increasing bile acid export via bile, and upregulating bile acid detoxification enzymes.

JOURNAL OF APPLIED TOXICOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Danyu Du et al.

Summary: Hepatocellular carcinoma is an aggressive cancer with increasing incidence worldwide. Targeting abnormal metabolism has emerged as a new strategy for HCC treatment. This review highlights metabolic targets and discusses current pharmaceutical agents and studies in this field.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ursolic Acid Analogs as Potential Therapeutics for Cancer

Siva S. Panda et al.

Summary: Ursolic acid (UA) is a pentacyclic triterpene with diverse pharmacological properties, including anti-inflammatory, antimicrobial, antiviral, antioxidant, and anti-proliferative activities. It holds promise as a cancer preventive and therapeutic agent due to its relatively non-toxic properties against normal cells but its activities against cancer cells. However, its low bioavailability limits its clinical applications. Researchers have been designing and developing synthetic analogs of UA to overcome this limitation and utilize its importance.

MOLECULES (2022)

添加到收藏夹

Article Cell Biology

Lipid desaturation regulates the balance between self-renewal and differentiation in mouse blastocyst-derived stem cells

Chanchal Thomas Mannully et al.

Summary: Stem cell self-renewal and differentiation are regulated by metabolism, specifically lipid desaturation. Inhibiting specific metabolic enzymes can maintain stem cell characteristics and reduce cell apoptosis. Monounsaturated fatty acids are beneficial for stem cells but detrimental to trophoblast cells.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Article Plant Sciences

Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis

Jianming Liu et al.

Summary: OA alleviates ANIT-induced cholestatic liver injury by regulating bile acid transporters and metabolic enzymes through the activation of Fxr and Nrf2 pathways.

PHYTOMEDICINE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Enhanced Water Solubility and Anti-Tumor Activity of Oleanolic Acid through Chemical Structure Modification

Zhicheng Gu et al.

Summary: Researching and developing highly water-soluble OA derivatives can improve their anti-tumor activity, while the poor water solubility of the original OA drug is one of the main reasons for its weak anti-tumor activity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Microemulsions Enhance the In Vitro Antioxidant Activity of Oleanolic Acid in RAW 264.7 Cells

Chiara De Stefani et al.

Summary: The study formulated oleanolic acid (OA) into two different microemulsions (ME-1 and ME-2) to enhance its solubility and intestinal permeability, leading to a significant increase in bioavailability. Both MEs showed enhanced intestinal permeability compared to free OA according to PAMPA assay results. The study suggests that MEs could be a promising formulation to improve the oral bioavailability of OA with potential clinical applications.

PHARMACEUTICS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hepatic Oleate Regulates Insulin-like Growth Factor-Binding Protein 1 Partially through the mTORC1-FGF21 Axis during High-Carbohydrate Feeding

Lucas M. O'Neill et al.

Summary: SCD1 deficiency enhances insulin signaling and whole-body glucose uptake, and protects against high-carbohydrate diet-induced obesity. IGFBP1 is significantly elevated in GKO and LKO mice, regulated by oleic acid (18:1n9).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Cell Biology

Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

Zhuoran Liang et al.

Aging-US (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review

Linfeng He et al.

Summary: Cholestasis can lead to severe liver diseases like hepatocyte damage, liver fibrosis, and cirrhosis, with Nrf2 pathway showing potential in alleviating the injury. Natural products containing Nrf2 activators have been highlighted as potential therapeutic options for cholestatic liver injury.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial

V. Ratziu et al.

Summary: Aramchol showed potential improvements in liver steatosis and fibrosis in NASH patients, but did not significantly reduce hepatic triglycerides. However, it demonstrated positive effects on liver histology and ALT levels in the clinical trial.

NATURE MEDICINE (2021)

添加到收藏夹

Review Chemistry, Medicinal

Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives

Xiaofan Zhang et al.

Summary: Oleanolic acid and its derivatives exhibit anti-inflammatory activity through various pathways, and research suggests that they may achieve their anti-inflammatory effects by regulating signaling pathways.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease

Siyu Yu et al.

Frontiers in Pharmacology (2021)

添加到收藏夹

Review Medicine, General & Internal

Non-alcoholic fatty liver disease

Elizabeth E. Powell et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.

LANCET (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Dietary carbohydrates and fats in nonalcoholic fatty liver disease

Hannele Yki-Jarvinen et al.

Summary: This review examines the role of dietary fats and carbohydrates in nonalcoholic fatty liver disease (NAFLD), emphasizing the benefits of diets reduced in free sugars, refined carbohydrates, and saturated fats for the treatment of NAFLD.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Article Nutrition & Dietetics

Metabolic effects of a prolonged, very-high-dose dietary fructose challenge in healthy subjects

Sabina Smajis et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

添加到收藏夹

Editorial Material Gastroenterology & Hepatology

Redefining non-alcoholic fatty liver disease: what's in a name?

[Anonymous]

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Article Cell Biology

Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

Ana Andres-Hernando et al.

CELL METABOLISM (2020)

添加到收藏夹

Review Oncology

Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women

Jing Yang et al.

CANCERS (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses

Jie Liu et al.

LIVER INTERNATIONAL (2019)

添加到收藏夹

Article Nutrition & Dietetics

Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet

Mashudu Given Matumba et al.

NUTRIENTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling

Dandan Sheng et al.

CELL AND BIOSCIENCE (2019)

添加到收藏夹

Review Nutrition & Dietetics

Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1)

Elena Piccinin et al.

NUTRIENTS (2019)

添加到收藏夹

Article Food Science & Technology

6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1

Li Liu et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Zobair Younossi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

David Hojland Ipsen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Protein engineering: Regulatory perspectives of stearoyl CoA desaturase

Shagufta Kamal et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

添加到收藏夹

Article Chemistry, Medicinal

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

Anroop Nair et al.

DRUG DEVELOPMENT RESEARCH (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate

Simon Ducheix et al.

GASTROENTEROLOGY (2018)

添加到收藏夹

Article Agriculture, Multidisciplinary

Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis

Yen-Ning Lin et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

添加到收藏夹

Review Nutrition & Dietetics

A review of total & added sugar intakes and dietary sources in Europe

Veronique Azais-Braesco et al.

NUTRITION JOURNAL (2017)

添加到收藏夹

Review Nutrition & Dietetics

Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease

Kasper W. ter Horst et al.

NUTRIENTS (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Oleate activates SREBP-1 signaling activity in SCD1 -deficient hepatocytes

Mohamed A. Lounis et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells

Fei-Fei Chen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats

Li Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis

Nobuya Kurikawa et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)

添加到收藏夹

Review Gastroenterology & Hepatology

Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

Seung-Hoi Koo

CLINICAL AND MOLECULAR HEPATOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance

Lu-Ping Ren et al.

PLOS ONE (2012)

添加到收藏夹

Review Physiology

Metabolic Effects of Fructose and the Worldwide Increase in Obesity

Luc Tappy et al.

PHYSIOLOGICAL REVIEWS (2010)

添加到收藏夹

Article Cell Biology

Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis

Makoto Miyazaki et al.

CELL METABOLISM (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms

M Miyazaki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

JM Ntambi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.