Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124

miR-124 is a miRNA predominantly expressed in the nervous system and accounts for more than a quarter of the total miRNAs in the brain. It regulates neurogenesis, neuronal differentiation, neuronal maturation, and synapse formation and is the most important miRNA in the brain. Furthermore, emerging evidence has suggested miR-124 may be associated with the pathogenesis of various neurodevelopmental and neuropsychiatric disorders. Here, we provide an overview of the role of miR-124 in neurodevelopment and the underling mechanisms, and finally, we prospect the significance of miR-124 research to the field of neuroscience.

Automated summary

miR-124, accounting for more than a quarter of total miRNAs in the brain, is a highly expressed miRNA in the nervous system. It plays important roles in regulating neurogenesis, neuronal differentiation, neuronal maturation, and synapse formation. Furthermore, it has been shown to be associated with the pathogenesis of various neurodevelopmental and neuropsychiatric disorders. This review provides an overview of the role and underlying mechanisms of miR-124 in neurodevelopment and prospects its significance in neuroscience research.