相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Structural Modeling of TRPA1 Ion Channel-Determination of the Binding Site for Antagonists
Alicja Gawalska et al.
MOLECULES (2022)
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Jack A. Terrett et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Big Data and Artificial Intelligence Modeling for Drug Discovery
Hao Zhu
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 60 (2020)
Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors
Yadan Huang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases
Martina Schmidt et al.
CURRENT OPINION IN PHARMACOLOGY (2020)
Phosphodiesterases as therapeutic targets for respiratory diseases
Haoxiao Zuo et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation
Stefano Alcaro et al.
FRONTIERS IN CHEMISTRY (2019)
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease
Tao Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Towards Automated Machine Learning: Evaluation and Comparison of AutoML Approaches and Tools
Anh Truong et al.
2019 IEEE 31ST INTERNATIONAL CONFERENCE ON TOOLS WITH ARTIFICIAL INTELLIGENCE (ICTAI 2019) (2019)
PDE8: A Novel Target in Airway Smooth Muscle
Haoxiao Zuo et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)
PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6
Timothy B. Johnstone et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)
Machine learning in chemoinformatics and drug discovery
Yu-Chen Lo et al.
DRUG DISCOVERY TODAY (2018)
Roles of roflumilast, a selective phosphodiesterase 4 inhibitor, in airway diseases
Theerasuk Kawamatawong
JOURNAL OF THORACIC DISEASE (2017)
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
Antoine Daina et al.
SCIENTIFIC REPORTS (2017)
TRP functions in the broncho-pulmonary system
Francesco De Logu et al.
SEMINARS IN IMMUNOPATHOLOGY (2016)
Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation
Amanda G. Vang et al.
FRONTIERS IN PHARMACOLOGY (2016)
Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?
Indranil Mukhopadhyay et al.
PHARMACEUTICALS (2016)
ZINC 15-Ligand Discovery for Everyone
Teague Sterling et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)
ChEMBL web services: streamlining access to drug discovery data and utilities
Mark Davies et al.
NUCLEIC ACIDS RESEARCH (2015)
Transient receptor potential ankyrin 1 (TRPA1) antagonists
Delia Preti et al.
PHARMACEUTICAL PATENT ANALYST (2015)
Development of novel azabenzofuran TRPA1 antagonists as in vivo tools
Katrina W. Copeland et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists
Yun-Jin Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro
J. Milara et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
TRP channels as therapeutic targets in airway disorders: a patent review
Delia Preti et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2012)
PaDEL-Descriptor: An Open Source Software to Calculate Molecular Descriptors and Fingerprints
Chun Wei Yap
JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)
The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland
Li-Chun Lisa Tsai et al.
MOLECULAR PHARMACOLOGY (2011)
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration
Michael D. Woodrow et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Perspectives on TRP Channel Structure and the TRPA1 Puzzle
Ramon Latorre
JOURNAL OF GENERAL PHYSIOLOGY (2009)
Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD
Zheng Huang et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers
R Barber et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)
Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease
D Spina
DRUGS (2003)
Atomic structure of PDE4: Insights into phosphodiesterase mechanism and specificity
RX Xu et al.
SCIENCE (2000)
分享论文
