The winding road toward transcriptional repression

Enhancers are known for their role in mediating transcriptional activation. In this issue, Vermunt et al.1 report the unexpected finding that genes can undergo a sequential transition between distinct enhancers to mediate progressive downregulation of expression.

Automated summary

Enhancers play a role in transcriptional activation. The study by Vermunt et al.1 reveals that genes can undergo sequential transitions between enhancers, leading to progressive downregulation of expression.