☆ 4.5 Article

EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma

MOLECULAR CANCER RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling

Xingkang Jiang et al.

Summary: This study reveals the important role of circARHGAP29 in docetaxel-resistant prostate cancer by promoting glycolytic metabolism. circARHGAP29 upregulation leads to docetaxel resistance and enhanced glycolytic metabolism, while silencing circARHGAP29 can reduce these effects.

CANCER RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development

Carline Chaves-Almagro et al.

Summary: This study investigated the expression and protumoral function of apelin and its receptor APJ in human pancreatic adenocarcinoma. It was found that apelin and APJ were co-expressed by tumor cells in the invasive stage, and apelin promoted cancer cell proliferation, migration, and glucose uptake. Blocking the apelin receptor reduced cancer cell proliferation and pancreatic tumor burden.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Oncology

EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling

Yutian Wei et al.

Summary: This study revealed that circASAP1 is upregulated in recurrent GBM tissues and TMZ-resistant cell lines, promoting GBM cell proliferation and TMZ resistance by increasing NRAS expression through sponging miR-502-5p. The findings suggest that ceRNA-mediated microRNA sequestration may be a potential therapeutic strategy for GBM treatment.

NEURO-ONCOLOGY (2021)

添加到收藏夹

Editorial Material Cell Biology

EIF4A3: a gatekeeper of autophagy

Despoina Sakellariou et al.

Summary: EIF4A3 has been identified as a negative regulator of autophagy, playing a role in maintaining low basal levels of autophagy through cytosolic retention of TFEB. Depletion of EIF4A3 leads to increased autophagic flux by inducing transcriptional responses for both early and late steps of the autophagy pathway. The upregulation of EIF4A3 in various cancer types highlights its potential significance as a therapeutic target.

AUTOPHAGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3

Xuehui Wang et al.

Summary: This study reveals the crucial role of hsa_circ_0068631 in breast cancer, showing that it regulates tumor biological activities by influencing the expression and stability of c-Myc. The findings provide a new target for breast cancer treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Long Non-Coding RNA CRNDE Is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR Signaling

Satoshi Takahashi et al.

Summary: This study identified that CRNDE is associated with the development of resistance to EGFR-TKIs in lung cancer cells. Inhibition of CRNDE activated the eIF4A3/MUC1/EGFR signaling pathway and apoptotic activity, restoring sensitivity to EGFR-TKIs. These findings suggest that CRNDE may be a potential therapeutic target for overcoming EGFR-mutant NSCLC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Oncology

EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway

Zhipeng Jiang et al.

Summary: The study revealed that circ_0084615 was upregulated in CRC tissues and associated with TNM stages, lymph node metastasis, differentiation, and overall survival rate. Knockdown of circ_0084615 inhibited CRC cell proliferation, migration, invasion, and angiogenesis in vitro and impeded tumorigenesis in vivo. Circ_0084615 acted as an oncogene in CRC development through the miR-599/ONECUT2 axis induced by EIF4A3.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Oncology

Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism

Samrita Dogra et al.

Summary: Adipocyte-derived apelin activates APJ-expressing tumor cells in a paracrine manner, promoting lipid uptake and utilization, providing energy for ovarian cancer cell survival at the metastatic sites. The apelin-APJ pathway presents a novel therapeutic target to curb ovarian cancer metastasis.

MOLECULAR CANCER RESEARCH (2021)

添加到收藏夹

Review Oncology

Eukaryotic Initiation Factor 4A-3: A Review of Its Physiological Role and Involvement in Oncogenesis

Jiazhou Ye et al.

Summary: EIF4A3 plays a crucial role in post-transcriptional gene regulation and maintains the expression of important proteins, but its overexpression is associated with tumorigenesis in various cancers. Further research is needed to elucidate its functions, mechanisms, and potential clinical applications, providing new insights and opportunities for cancer diagnosis and treatment.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3

Fangpu Yu et al.

Summary: This study identified the role of hsa_circ_0030042 in regulating abnormal autophagy of endothelial cells and plaque stability via modulating eIF4A3. This new pathway may serve as a potential therapeutic strategy against cardiovascular diseases like coronary heart disease.

THERANOSTICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Apelin/APJ system: an emerging therapeutic target for respiratory diseases

Jialong Yan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

添加到收藏夹

Article Respiratory System

Lung Cancer 2020 Epidemiology, Etiology, and Prevention

Brett C. Bade et al.

CLINICS IN CHEST MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

Xiaying Zheng et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Article Medicine, General & Internal

Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes

Na Li et al.

EPMA JOURNAL (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The relationship between autophagy and the immune system and its applications for tumor immunotherapy

Guan-Min Jiang et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Oncology

FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma

Louqian Zhang et al.

THORACIC CANCER (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sumoylation of Flotillin-1 promotes EMT in metastatic prostate cancer by suppressing Snail degradation

Donghwan Jang et al.

ONCOGENE (2019)

添加到收藏夹

Article Oncology

Flotillin1 promotes EMT of human small cell lung cancer via TGF-β signaling pathway

Lianmei Zhao et al.

CANCER BIOLOGY & MEDICINE (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

Guangbo Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

添加到收藏夹

Review Medicine, General & Internal

Lung cancer: current therapies and new targeted treatments

Fred R. Hirsch et al.

LANCET (2017)

添加到收藏夹

Article Oncology

Flotilin-1 promotes the tumorigenicity and progression of malignant phenotype in human lung adenocarcinoma

Ai Yun Guo et al.

CANCER BIOLOGY & THERAPY (2017)

添加到收藏夹

Article Chemistry, Medicinal

ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A

Joseph Tillotson et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

添加到收藏夹

Article Oncology

Targeted Therapy and Immunotherapy for Lung Cancer

Evan C. Naylor et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

Farheen Raza et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting the eIF4A RNA helicase as an anti-neoplastic approach

Jennifer Chu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)

添加到收藏夹

Review Oncology

The 2015 World Health Organization Classification of Lung Tumors Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification

William D. Travis et al.

JOURNAL OF THORACIC ONCOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

The diverse roles of the eIF4A family: you are the company you keep

Wei-Ting Lu et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer

Laisheng Li et al.

MOLECULAR CANCER (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of a signature motif for the eIF4a3-SECIS interaction

Michael E. Budiman et al.

NUCLEIC ACIDS RESEARCH (2011)

添加到收藏夹

Article Medicine, Research & Experimental

PI3K signaling of autophagy is required for starvation tolerance and virulence of Cryptocloccus neoformans

Guowu Hu et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

Scaffolding microdomains and beyond: the function of reggie/flotillin proteins

MF Langhorst et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals

AJ Edgar et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A

K Holzmann et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.