Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs

Article Cell Biology

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

Yingying Han et al.

Summary: The study reveals the intrinsic requirement of Zeb1 in mammary epithelial ductal side branching and basal cell regenerative capacity. Zeb1 maintains both basal cell fate and stem cell quiescence partly through suppressing Wnt signaling.

CELL REPORTS (2022)

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Article Multidisciplinary Sciences

Clinical features and prognostic impact of asymptomatic pancreatic cancer

Tetsuya Takikawa et al.

Summary: This study reviewed the data of 577 patients with pancreatic ductal adenocarcinoma (PDAC) and found that the diagnosis of asymptomatic PDAC is associated with early diagnosis and a better prognosis. In asymptomatic PDAC, the tumors are smaller, the disease is in an earlier stage, and the resectability is higher.

SCIENTIFIC REPORTS (2022)

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Article Medicine, Research & Experimental

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Angela M. Araujo et al.

Summary: This study reveals the pivotal role of the cytokine oncostatin M (OSM) in regulating interactions between immune and nonimmune stromal cells and epithelial cancer cells. It demonstrates that the stromal OSM/OSMR axis reprograms the tumor microenvironment and plays a key role in breast cancer progression.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Medicine, Research & Experimental

EMT, cancer stem cells and autophagy; The three main axes of metastasis

Ghader Babaei et al.

Summary: Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to cancer cell metastasis. Autophagy has recently gained attention, playing a dual role in cancer cell development depending on cancer type, tissue, and stage. Studies show different signaling pathways are involved in cancer stem cells, autophagy, and EMT. Investigating effective signaling pathways in all three processes could help determine appropriate therapeutic goals.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Oncology

MEK inhibitor resistance mechanisms and recent developments in combination trials

E. Kun et al.

Summary: The MAPK pathway is crucial in cancer development, and drugs targeting this pathway, especially MEK inhibitors, have shown promise. However, research and solutions regarding adaptive resistance mechanisms to MEK inhibitors are still challenging.

CANCER TREATMENT REVIEWS (2021)

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Article Oncology

Exploring the oncostatin M (OSM) feed-forward signaling of glioblastoma via STAT3 in pan-cancer analysis

Miao Chen et al.

Summary: This study conducted a pan-cancer analysis on OSM, showing higher expression of OSM in most tumor tissues compared to normal tissues, with a strong correlation to poor prognosis in several cancers. OSM expression was related to stromal and immune cell infiltration in the tumor microenvironment, as well as immune checkpoint and chemokine co-expression. In GBM, OSM was found to stimulate malignant cells through the Jak-STAT and NF-kappa B pathways, and could facilitate migration and invasion of glioblastoma cells. The study indicates that OSM may serve as a potential immunotherapeutic target for cancer treatment.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Aberrant Induction of a Mesenchymal/Stem Cell Program Engages Senescence in Normal Mammary Epithelial Cells

Benjamin L. Bryson et al.

Summary: The study demonstrates that inflammatory cytokines can induce cellular senescence and promote the formation of cancer stem cells. By combining CDK4/6 inhibition with senolytic therapy, cancer stem cells can be efficiently killed.

MOLECULAR CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Brian Y. Lee et al.

Summary: The study highlights the crucial role of macrophage-derived Oncostatin M in reprogramming cancer-associated fibroblasts to drive a pro-tumorigenic environment in pancreatic ductal adenocarcinoma.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Lizhi He et al.

Summary: Macrophages undergoing M1 versus M2-type polarization exhibit significant differences in cell metabolism, cellular functions, and signaling pathways, especially in metabolic pathways. Drug screens have identified inhibitors that selectively block M2-type polarization, with MEK signaling being found necessary for M2-type polarization in a proof-of-principle study using comprehensive proteomics and phosphoproteomics datasets.

CELL REPORTS (2021)

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Article Oncology

Characterisation of circulating tumour cell phenotypes identifies a partial-EMT sub-population for clinical stratification of pancreatic cancer

Alexander Semaan et al.

Summary: DEP-FFF was used to isolate CTCs in PDAC patients, revealing four distinct sub-populations including pEMT-CTCs, which were correlated with disease progression, survival, and recurrence. This highlights the importance of immunophenotyping and quantifying specific CTC sub-populations in PDAC.

BRITISH JOURNAL OF CANCER (2021)

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Review Cell Biology

Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer

Edward P. Carter et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to challenges in treatment and late detection, with the FGFR signalling pathway playing a critical role in tumor progression and interaction with the tumor microenvironment. However, it is clear that the FGFR signalling pathway does not act in isolation and interacts with other signaling networks. Therapeutic approaches are being developed to improve prognosis for this terrible disease.

CELLS (2021)

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Article Oncology

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

Toshiro Hara et al.

Summary: The mesenchymal subtype of glioblastoma is believed to be influenced by both cancer cell-intrinsic alterations and external cellular interactions, with macrophages inducing a transition of glioblastoma cells into mesenchymal-like states. This transition is mediated by macrophage-derived oncostatin M (OSM) interacting with its receptors on glioblastoma cells, leading to the activation of STAT3. This study also reveals that mesenchymal-like glioblastoma states are associated with increased expression of a mesenchymal program in macrophages and enhanced cytotoxicity of T cells, suggesting potential therapeutic implications.

CANCER CELL (2021)

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Article Oncology

Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Anjali Geethadevi et al.

Summary: This study reveals that elevated OSMR in ovarian cancer promotes cancer cell proliferation and metastasis through STAT3 signaling activation, and demonstrates the potential efficacy of antibody targeting OSMR for ovarian cancer treatment.

CANCER RESEARCH (2021)

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Article Health Care Sciences & Services

Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation

Andras Lanczky et al.

Summary: The web-based tool introduced in this study enables univariate and multivariate Cox proportional hazards survival analysis using data from various genomic studies, filling a significant gap in the field where no commonly used spreadsheet software or web server is available for this purpose.

JOURNAL OF MEDICAL INTERNET RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The JAK/STAT signaling pathway: from bench to clinic

Xiaoyi Hu et al.

Summary: The JAK/STAT signaling pathway is a crucial cellular signal transduction pathway, associated with various cancers and autoimmune diseases. Researchers discussed the composition, activation, and regulation of this pathway, as well as its role in diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

Fanglong Wu et al.

Summary: CAFs play vital roles in cancer progression and their complex signaling pathways with cancer cells are crucial for understanding the development of cancer.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Oncology

Novel mechanism for OSM-promoted extracellular matrix remodeling in breast cancer: LOXL2 upregulation and subsequent ECM alignment

Simion C. Dinca et al.

Summary: High co-expression of LOXL2 and OSM in IDC patients is associated with worse metastasis-free survival rates, while high levels of either individually are less impactful; LOXL2 expression is positively correlated with OSM/OSM receptor (OSMR) expression in IDC patients. Additionally, OSM-induced LOXL2 promotes an increase in ECM collagen I fiber crosslinking, leading to significant fiber alignment between cells and increased IDC cell invasion.

BREAST CANCER RESEARCH (2021)

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Article Medicine, Research & Experimental

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis

Toni Celia-Terrassa et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

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Review Gastroenterology & Hepatology

Pancreatic cancer stroma: an update on therapeutic targeting strategies

Abdel N. Hosein et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Multidisciplinary Sciences

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation

Ahmad Sharanek et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

Wells S. Brown et al.

CELL REPORTS MEDICINE (2020)

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Review Oncology

Non-genetic mechanisms of therapeutic resistance in cancer

Jean-Christophe Marine et al.

NATURE REVIEWS CANCER (2020)

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Review Pharmacology & Pharmacy

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

Mohit Kumar Jolly et al.

PHARMACOLOGY & THERAPEUTICS (2019)

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Article Multidisciplinary Sciences

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

Cornelia Kroger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Oncology

New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer

Noura Khaled et al.

CANCERS (2019)

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Article Multidisciplinary Sciences

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors

Emily A. Irey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Immunology

Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor

Emma Persson et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Cell Biology

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression

Qixia Xu et al.

AGING CELL (2019)

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Review Surgery

Meta-analysis of recurrence pattern after resection for pancreatic cancer

M. Tanaka et al.

BRITISH JOURNAL OF SURGERY (2019)

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Article Oncology

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

Xia Liu et al.

CANCER DISCOVERY (2019)

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Article Oncology

The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer

Mary R. Doherty et al.

BREAST CANCER RESEARCH (2019)

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Article Chemistry, Analytical

Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis

Yu-Chih Chen et al.

ANALYST (2019)

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Interleukin-6 Family Cytokines

Stefan Rose-John

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets

Nese Unver et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

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Article Oncology

The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis

Ilary Ruscito et al.

GYNECOLOGIC ONCOLOGY (2018)

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Article Oncology

Ruxolitinib plus capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies

Herbert Hurwitz et al.

INVESTIGATIONAL NEW DRUGS (2018)

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Article Oncology

Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma

Justyna A. Kucia-Tran et al.

JOURNAL OF PATHOLOGY (2018)

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Article Multidisciplinary Sciences

Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer

N. Hojo et al.

SCIENTIFIC REPORTS (2018)

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Review Cell Biology

Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells

Francis O. Enane et al.

CELL DEATH & DISEASE (2018)

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Review Cell & Tissue Engineering

Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells

Petra Gener et al.

STEM CELLS INTERNATIONAL (2018)

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Article Oncology

OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung

Ken Tawara et al.

BREAST CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

Aleksandra Adamska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Oncology

Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer

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MOLECULAR CANCER RESEARCH (2017)

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Article Oncology

JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer

Kazuhiko Shien et al.

MOLECULAR CANCER THERAPEUTICS (2017)

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Article Biochemistry & Molecular Biology

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

Nathaniel R. West et al.

NATURE MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling

D. J. Junk et al.

ONCOGENE (2017)

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Article Neurosciences

Control of glioblastoma tumorigenesis by feed-forward cytokine signaling

Arezu Jahani-Asl et al.

NATURE NEUROSCIENCE (2016)

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Article Multidisciplinary Sciences

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

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NATURE (2015)

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Article Multidisciplinary Sciences

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Devon A. Lawson et al.

NATURE (2015)

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Article Oncology

Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors

Margarida Ferreira-Teixeira et al.

ONCOTARGET (2015)

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Article Oncology

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma

Maria Ines Molejon et al.

ONCOTARGET (2015)

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Article Oncology

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

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CANCER CELL (2014)

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Article Oncology

A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas

Jeffrey R. Infante et al.

EUROPEAN JOURNAL OF CANCER (2014)

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Article Gastroenterology & Hepatology

Serum Cytokine Profile in Patients With Pancreatic Cancer

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PANCREAS (2014)

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Article Medicine, General & Internal

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

Daniel D. Von Hoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Tumor Microenvironmental Signaling Elicits Epithelial-Mesenchymal Plasticity through Cooperation with Transforming Genetic Events

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Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

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Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

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EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

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CANCER CELL (2012)

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Article Oncology

Oncostatin M Modulates the Mesenchymal-Epithelial Transition of Lung Adenocarcinoma Cells by a Mesenchymal Stem Cell-Mediated Paracrine Effect

Mong-Lien Wang et al.

CANCER RESEARCH (2012)

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Article Medicine, Research & Experimental

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

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JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Oncology

Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer

Panayiotis A. Theodoropoulos et al.

CANCER LETTERS (2010)

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Article Oncology

ONCOMINE: A cancer microarray database and integrated data-mining platform

DR Rhodes et al.

NEOPLASIA (2004)

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Non-redundant signal transduction of interleukin-6-type cytokines - The adapter protein Shc is specifically recruited to the oncostatin M receptor

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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs

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