Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation (vol 20, 88, 2021)

Summary: Cancer metastasis is the main cause of mortality, with the identification of new therapeutic targets being crucial for survival improvement. Through the study of intratumoral heterogeneity, Lymphocyte cell-specific protein-tyrosine kinase (LCK) was discovered as a significant regulator of motility in oral cancer cells, suggesting that inhibition of LCK could be a promising anti-metastasis therapy option for oral cancer patients.