Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis

Article Biochemistry & Molecular Biology

CircRNA_0040705 promotes the progression of hepatocellular carcinoma

Yanxia Li et al.

Summary: This study found that circ_0040705 promotes the growth, migration, and invasion of hepatocellular carcinoma (HCC) cells by down-regulating miR-557 and up-regulating SOX2 expression.

IUBMB LIFE (2022)

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Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

The long non-coding RNA ASMTL-AS1 promotes hepatocellular carcinoma progression by sponging miR-1343-3p that suppresses LAMC1 (laminin subunit gamma 1)

Yanjie Mou et al.

Summary: This study found that ASMTL-AS1 plays a carcinogenic role in hepatocellular carcinoma (HCC) by interacting with miR-1343-3p and LAMC1 through the competing endogenous RNA (ceRNA) mechanism, thereby interfering with the malignant behavior of HCC cells.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis

Yu Cai et al.

Summary: This study investigates the role of circ-SOX5 in hepatocellular carcinoma (HCC) and finds that circ-SOX5 promotes the development of HCC by regulating cell apoptosis. Circ-SOX5 may be a potential biomarker of HCC.

BIOENGINEERED (2022)

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Article Oncology

circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis

Donghong Liu et al.

Summary: In this study, circKCNN2 was identified as a potential predictive biomarker and therapeutic agent for the recurrence of hepatocellular carcinoma (HCC). Through multi-omics analyses, circKCNN2 was found to suppress the recurrence of HCC via the miR-520c-3p/MBD2 axis. These findings suggest that circKCNN2 may hold promise for predicting HCC recurrence and improving therapeutic outcomes.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis

Long Wan et al.

Summary: This study revealed that circRNA trefoil factor 1 (circ-TFF1) plays a crucial role in breast cancer (BC) progression by regulating the miR-338-3p/FGFR1 axis, suppressing BC cell proliferation, invasion, and glycolysis. The findings suggest circ-TFF1 as a promising therapeutic target for BC.

BIOCHEMICAL GENETICS (2022)

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Article Medical Laboratory Technology

circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing the expression of PD-L1 through NF-κB pathway

Fan Wu et al.

Summary: The study revealed that circCORO1C can activate the NF-kappa B signaling pathway, leading to increased P65 phosphorylation and upregulation of c-Myc and COX-2, resulting in increased PD-L1 expression which promotes the development of HCC.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Editorial Material Oncology

LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis

You-Quan Wang et al.

Summary: The SNHG6/miR-543/LAMC1 axis plays a crucial role in breast cancer by regulating cell proliferation, migration, invasion, and apoptosis, promoting the development of the disease. This study provides a new direction for the development of therapeutic strategies for breast cancer.

BREAST CANCER RESEARCH AND TREATMENT (2021)

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Article Oncology

CircRNA in cancer: Fundamental mechanism and clinical potential

Liang Chen et al.

Summary: Circular RNAs play crucial roles in tumorigenesis and tumor development by promoting or suppressing cancers through different molecular mechanisms. With advancements in nucleic acid-based therapeutic tools, circRNAs could be explored as targetable molecules in future cancer treatments.

CANCER LETTERS (2021)

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Article Gastroenterology & Hepatology

Circular ribonucleic acid nei-like deoxyribonucleic acid glycosylase 3 governs the microribonucleic acid-3150b-3p/laminin subunit gamma 1 network to partially promote the development of hepatocellular carcinoma

Zhenjie Li et al.

Summary: CircNEIL3 dysregulation contributes to HCC development by modulating the miR-3150b-3p/LAMC1 regulatory network. Knockdown of circNEIL3 inhibits HCC cell proliferation, migration, and invasion while inducing apoptosis and cell cycle arrest. MiR-3150b-3p is a target of circNEIL3, and LAMC1 is a target of miR-3150b-3p, with their interactions playing crucial roles in HCC progression.

HEPATOLOGY RESEARCH (2021)

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Review Oncology

Circular RNAs: characteristics, biogenesis, mechanisms and functions in liver cancer

Hao Shen et al.

Summary: Circular RNAs (circRNAs) are a novel class of noncoding RNAs that play a significant role in the initiation and progression of HCC, but their internal mechanisms and clinical applications require further investigation.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Oncology

LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3

Lingling Fang et al.

Summary: This study identified a dual mechanism by which TGF beta upregulates LAMC1 in tumor cells, promoting ESCC proliferation and migration, as well as indirectly inducing carcinogenesis by stimulating CXCL1 secretion to promote the formation of inflammatory CAF. This finding suggests that LAMC1 could be a potential therapeutic target and prognostic marker for ESCC.

MOLECULAR ONCOLOGY (2021)

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Article Oncology

MicroRNA-8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self-renewal of colorectal cancer stem cells via the Wnt/β-catenin pathway

Zheng-Quan Chen et al.

Summary: This study identified miR-8063 as a tumor suppressor involved in regulating the self-renewal of CRCSCs, where loss of miR-8063 expression weakens its inhibition on hnRNPAB, leading to the activation of the Wnt/beta-catenin signaling pathway to promote CRCSCs self-renewal.

ONCOLOGY REPORTS (2021)

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Article Medical Laboratory Technology