Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4

Article Gastroenterology & Hepatology

TCN1 Deficiency Inhibits the Malignancy of Colorectal Cancer Cells by Regulating the ITGB4 Pathway

Xinqiang Zhu et al.

Summary: This study reveals that TCN1 may play an oncogenic role in colorectal cancer by regulating the ITGB4 signaling pathway, providing insights into the potential molecular mechanisms underlying CRC development and metastasis.

GUT AND LIVER (2023)

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Review Biochemistry & Molecular Biology

Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis

Vladimir V. Sobolev et al.

Summary: This review focuses on the importance of the transcription factor FOSL1 in cell differentiation and tumorigenesis. It summarizes the role of FOSL1 in the differentiation of various cell lineages and its control over tumor progression through epithelial-mesenchymal transformation. The review also provides comprehensive analysis of FOSL1's influence on gene expression and discusses its role in human cancers, including its expression pattern, importance as a prognostic factor, and potential as a molecular target for anticancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Physiology

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

Giulia Biffi et al.

Summary: Efforts to develop anti-cancer therapies have mainly targeted the epithelial compartment, but recent studies have shown the significant influence of cancer-associated fibroblasts (CAFs) in tumor progression. CAFs not only promote cancer cell proliferation, therapy resistance, and immune exclusion, but may also restrain tumor progression in certain contexts. Research on CAFs has focused on their heterogeneity, plasticity, and functions across different cancer types and states, as well as advancements in therapeutic strategies targeting CAFs currently undergoing preclinical and clinical evaluation.

PHYSIOLOGICAL REVIEWS (2021)

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Article Medicine, Research & Experimental

Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis

Lin Zhou et al.

Summary: The study revealed that exosomal LINC00659 derived from CAFs promotes CRC cell proliferation, invasion, and migration through the miR-342-3p/ANXA2 pathway.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Pharmacology & Pharmacy

FOSL1 promotes tumorigenesis in colorectal carcinoma by mediating the FBXL2/Wnt/β-catenin axis via Smurf1

Yi Liu et al.

Summary: In this study, elevated expression of Fosl1 in colorectal carcinoma tissues was associated with poor prognosis and promoted cell viability, epithelial-to-mesenchymal transition, migration, and invasion. Silencing of Fosl1 in vivo inhibited lung, liver, and kidney metastases. The interaction between Fosl1 and Smurf1 was identified as a mechanism contributing to the malignant aggressiveness of colorectal carcinoma cells. This suggests that Fosl1 inhibition could be a potential prognostic and therapeutic strategy for colorectal carcinoma.

PHARMACOLOGICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Cancer associated-fibroblast-derived exosomes in cancer progression

Chao Li et al.

Summary: Research focuses on various cell types in the tumor microenvironment (TME), particularly on understanding the role of cancer-associated fibroblasts (CAFs) in influencing the communication between cancer cells and other TME cells through the secretion of extracellular vesicles (exosomes). Studies have shown that CAFs play a significant role in tumor progression by remodeling the extracellular matrix, secreting factors, and exosomes.

MOLECULAR CANCER (2021)

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Article Gastroenterology & Hepatology

FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

Adrian Vallejo et al.

Summary: The transcription factor FOSL1 plays a crucial role in the development and progression of cholangiocarcinoma (CCA), and its downstream effectors are susceptible to pharmacological inhibition, providing new opportunities for therapeutic intervention in CCA.

JOURNAL OF HEPATOLOGY (2021)

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Article Biotechnology & Applied Microbiology

FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program

Ming Zhang et al.

Summary: This study revealed that FOSL1 is significantly upregulated in HNSCC tumor tissues and promotes tumorigenicity and metastasis by establishing super-enhancers at cancer stemness and pro-metastatic genes. The abundance of FOSL1 is positively associated with SNAI2, and high expression levels of both genes are correlated with shorter disease-free survival. Inhibiting FOSL1 with the inhibitor SR11302 significantly suppressed tumor growth and lymph node metastasis in a patient-derived xenograft model, suggesting FOSL1 as a potential therapeutic target for HNSCC metastasis.

MOLECULAR THERAPY (2021)

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Review Pharmacology & Pharmacy

Tumor microenvironment as a therapeutic target in cancer

Yi Xiao et al.

Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Biochemistry & Molecular Biology

Regulation Network of Colorectal-Cancer-Specific Enhancers in the Progression of Colorectal Cancer

Bohan Chen et al.

Summary: The study revealed the regulatory network of colorectal-cancer-specific enhancers, which are associated with changes in over 50% of the topological associated domains (TADs) and interact with 152 genes that are significantly highly expressed in colorectal cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Clinical and therapeutic relevance of cancer-associated fibroblasts

Yang Chen et al.

Summary: CAFs, as highly versatile and resilient cells in primary and metastatic tumors, play crucial roles in cancer progression through complex interactions with other cell types in the tumor microenvironment. Their heterogeneity and dynamic interactions are key factors in cancer development.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Cell Biology

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

Chao Dai et al.

Summary: Metastasis is a complex and poorly understood process, especially in pancreatic cancer where loss of SMAD4 is correlated with metastatic disease and poor prognosis. This study identified FOSL1 as a SMAD4 target that plays a critical role in driving colonization to the lung, suggesting that early targeting of these genes may provide therapeutic benefits.

CELL REPORTS (2021)

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Article Oncology

ITGB4 as a novel serum diagnosis biomarker and potential therapeutic target for colorectal cancer

Xia Jiang et al.

Summary: ITGB4 shows high sensitivity but not high specificity in diagnosing CRC. Combining with CEA can improve diagnostic efficacy. Expression characteristics of ITGB4 at the single-cell level are related to drug sensitivity.

CANCER MEDICINE (2021)

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Article Medicine, Research & Experimental

Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer

Xijuan Chen et al.

Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology