4.7 Article

Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

A statistical approach to boost soluble expression of E. coli-derived virus-like particles in shake-flask cultivation

Nhat Hoang Huynh et al.

Summary: This study used a statistical approach to optimize the expression conditions of HBc-VLP in the Escherichia coli expression system. The results showed that post-induction temperature and shaker-speed had a significant impact on the protein yield. Additionally, sufficient oxygen level was required during induction.

JOURNAL OF BIOTECHNOLOGY (2022)

Review Chemistry, Analytical

A review on corona virus disease 2019 (COVID-19): current progress, clinical features and bioanalytical diagnostic methods

Fariba Mollarasouli et al.

Summary: This paper summarizes the COVID-19 pandemic, clinical features, epidemiology, and pathogenesis. It also focuses on recent advances in bioanalytical diagnostic methods for SARS-CoV-2 sensing. Additionally, it presents the mechanisms, advantages, and disadvantages of the most common biosensors for COVID-19 detection.

MICROCHIMICA ACTA (2022)

Article Biotechnology & Applied Microbiology

In vitro assembly of chimeric virus-like particles composed of a porcine circovirus 2b capsid protein and a B-cell epitope of infectious bursal disease virus

Xiaomeng Sun et al.

Summary: A method for in vitro assembly of recombinant proteins into chimeric virus-like particles was developed in this study. By specific steps of processing the fusion protein, typical and immunogenic particles were successfully obtained.

BIOTECHNOLOGY LETTERS (2022)

Article Immunology

Chimeric Virus-like Particle-Based COVID-19 Vaccine Confers Strong Protection against SARS-CoV-2 Viremia in K18-hACE2 Mice

Challika Kaewborisuth et al.

Summary: This study describes the immunogenicity of a chimeric VLP-based COVID-19 vaccine and demonstrates its strong protection against SARS-CoV-2 viremia in mice.

VACCINES (2022)

Review Biotechnology & Applied Microbiology

Development of virus-like particles-based vaccines against coronaviruses

Chean Yeah Yong et al.

Summary: SARS-CoV, MERS-CoV, and SARS-CoV-2 are the most impactful coronaviruses in human history, particularly SARS-CoV-2 which has brought revolutionary changes to vaccinology. Although 10 vaccines have been approved for emergency use against SARS-CoV-2, none of them are based on virus-like particles (VLPs). This review focuses on discussing the major advances in VLP-based vaccine candidates against these coronaviruses.

BIOTECHNOLOGY PROGRESS (2022)

Article Virology

A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants

Ching-Wen Chang et al.

Summary: Researchers have successfully generated a human cell line for studying SARS-CoV-2 by transducing human ACE2 and TMPRSS2 into A549 cells. These cells are susceptible to infection by SARS-CoV-2, including the delta and omicron variants. Additionally, several antiviral drugs showed strong inhibitory effects against SARS-CoV-2 variants in this cell model.

VIRUSES-BASEL (2022)

Article Microbiology

RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge

Ting Y. Wong et al.

Summary: Global distribution of COVID-19 vaccines to low-income countries has been a major challenge. The developed RBD virus-like particle (VLP) vaccines showed efficacy in preclinical mouse studies and can help alleviate vaccine shortages in these countries.

MSPHERE (2022)

Article Biotechnology & Applied Microbiology

Genetically engineered fusion of allergen and viral-like particle induces a more effective allergen-specific immune response than a combination of them

Maryam Zamani Sani et al.

Summary: Chimeric HBc VLPs exhibited low IgE-binding capacity and basophil degranulation activity, but induced higher levels of specific IgG antibodies and Th1 cell responses compared to recombinant Che a 3 or alum mixed with HBc VLPs. Genetically fusing allergen derivatives to HBc VLPs may be a more effective approach in allergen-specific immunotherapy.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

Saghi Nooraei et al.

Summary: Virus-like particles (VLPs) are virus-derived structures without genetic material, able to self-assemble and mimic viruses, utilized in candidate vaccines and successful applications in targeted drug delivery and gene therapy. Modifying the surface of VLPs for increased specificity and longevity in specific cells or tissues may enhance their future use.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Immunology

A Novel Double Mosaic Virus-like Particle-Based Vaccine against SARS-CoV-2 Incorporates Both Receptor Binding Motif (RBM) and Fusion Domain

Xinyue Chang et al.

Summary: A novel double mosaic vaccine displaying two independent neutralizing epitopes of SARS-CoV-2 virus was developed, inducing high levels of antibodies including neutralizing antibodies. This vaccine candidate, CuMVTT-DF, containing both RBM and fusion peptide, showed higher levels of neutralizing antibodies and could be a promising candidate for scale-up production in bacterial fermentation for clinical development.

VACCINES (2021)

Article Nanoscience & Nanotechnology

Immunogenicity and Vaccine Efficacy Boosted by Engineering Human Heavy Chain Ferritin and Chimeric Hepatitis B Virus Core Nanoparticles

Yiran Qu et al.

Summary: This study investigates the immunogenicity differences between engineered HFn and chimeric HBc bearing the same epitope, with results showing that HBc carrier induces a stronger humoral immune response, while HFn generates a stronger cell-mediated immune response.

ACS APPLIED BIO MATERIALS (2021)

Review Multidisciplinary Sciences

SARS-CoV-2 vaccines in development

Florian Krammer

NATURE (2020)

Review Immunology

Escherichia coli-derived virus-like particles in vaccine development

Xiaofen Huang et al.

NPJ VACCINES (2017)

Article Multidisciplinary Sciences

Yield Optimisation of Hepatitis B Virus Core Particles in E-coli Expression System for Drug Delivery Applications

Izzat Fahimuddin Bin Mohamed Suffian et al.

SCIENTIFIC REPORTS (2017)

Review Biotechnology & Applied Microbiology

Virus-like particles: Next-generation nanoparticles for targeted therapeutic delivery

Marcus J. Rohovie et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2017)

Review Biotechnology & Applied Microbiology

The application of virus-like particles as vaccines and biological vehicles

Dan Yan et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)

Review Biotechnology & Applied Microbiology

Production and applications of engineered viral capsids

Jeff Glasgow et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Bioengineering Virus-Like Particles as Vaccines

Linda H. L. Lua et al.

BIOTECHNOLOGY AND BIOENGINEERING (2014)

Review Biochemical Research Methods

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

William A. Rodriguez-Limas et al.

CURRENT OPINION IN BIOTECHNOLOGY (2013)

Review Immunology

Hepatitis B core-based virus-like particles to present heterologous epitopes

Kenny Roose et al.

EXPERT REVIEW OF VACCINES (2013)

Review Biochemistry & Molecular Biology

Construction and Characterization of Virus-Like Particles: A Review

Andris Zeltins

MOLECULAR BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Microbial production of virus-like particle vaccine protein at gram-per-litre levels

Mervyn W. O. Liew et al.

JOURNAL OF BIOTECHNOLOGY (2010)

Review Virology

HBV core particles as a carrier for B cell/T cell epitopes

P Pumpens et al.

INTERVIROLOGY (2001)