☆ 4.5 Editorial Material

Do selenium-enriched foods provide cognitive benefit?

METABOLIC BRAIN DISEASE (2023)

SELENOM Knockout Induces Synaptic Deficits and Cognitive Dysfunction by Influencing Brain Glucose Metabolism

Shujing Lin et al.

Summary: Our study demonstrates that SELENOM knockout in mice results in decreased synaptic plasticity and memory impairment. Furthermore, SELENOM knockout leads to hyperglycemia and disrupts glucose metabolism, which is crucial for synapse formation and transmission in the brain. The inhibition of the brain insulin signaling pathway is identified as the underlying mechanism for the synaptic deficits and cognitive dysfunction observed in SELENOM knockout mice.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Editorial Material Endocrinology & Metabolism

Selenium and cognitive function

Shuang-Qing Zhang

METABOLIC BRAIN DISEASE (2023)

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Review Food Science & Technology

Selenium-enriched foods and their ingredients: As intervention for the vicious cycle between autophagy and overloaded stress responses in Alzheimer's disease

Mengfei Chen et al.

Summary: Excessive ROS and inflammation lead to dysfunctional autophagy in Alzheimer's disease. Selenium-enriched ingredients (SEIs), including selenoproteins, selenoamino acids, and selenosugars, have shown potential in improving AD through antioxidant, anti-inflammatory, and autophagy-modulating effects. This review highlights that SEIs can eliminate ROS, alleviate inflammation, activate the AMPK/mTOR pathway, promote Aβ clearance, and reduce memory impairments, making them a potential novel strategy for AD treatment.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Article Clinical Neurology

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE)

Richard J. Kryscio et al.

JAMA NEUROLOGY (2017)

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Review Biochemistry & Molecular Biology

From selenium to selenoproteins: Synthesis, identity, and their role in human health

Laura Vanda Papp et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

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Do selenium-enriched foods provide cognitive benefit?

相关参考文献

SELENOM Knockout Induces Synaptic Deficits and Cognitive Dysfunction by Influencing Brain Glucose Metabolism

Selenium and cognitive function

Selenium-enriched foods and their ingredients: As intervention for the vicious cycle between autophagy and overloaded stress responses in Alzheimer's disease

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE)

From selenium to selenoproteins: Synthesis, identity, and their role in human health

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