Comprehensive analysis of m6A modification lncRNAs in high glucose and TNF-α induced human umbilical vein endothelial cells

Article Endocrinology & Metabolism

Irisin rescues diabetic cardiac microvascular injury via ERK1/2/Nrf2/HO-1 mediated inhibition of oxidative stress

Di Zhu et al.

Summary: Irisin can rescue cardiac microvessels against oxidative stress and apoptosis in diabetes via the ERK1/2/Nrf2/HO-1 pathway.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

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Article Cell Biology

Integrated analysis of transcriptome profiling of lncRNAs and mRNAs in livers of type 2 diabetes mellitus

Xi Lan et al.

Summary: This study compared the transcriptome profiling of lncRNAs and mRNAs in livers between patients with T2DM and controls. It identified differentially expressed lncRNAs and mRNAs, revealed dysregulated metabolic processes, constructed protein-protein interaction network, and predicted regulatory patterns and competing endogenous RNA network. The findings contribute to understanding the molecular mechanisms and identifying effective biomarkers in T2DM.

PHYSIOLOGICAL GENOMICS (2022)

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Article Cell Biology

METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA

Liping Meng et al.

Summary: This study reveals the important role of METTL14-mediated m6A methylation and lncRNA regulation in pyroptosis and DCM. The results show that METTL14 suppresses pyroptosis and DCM by downregulating lncRNA TINCR, and the underlying mechanisms involve m6A methylation and RNA degradation.

CELL DEATH & DISEASE (2022)

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Article Cell & Tissue Engineering

Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells

Liping Su et al.

Summary: This study aimed to evaluate the effect of thymosin beta-4 (Tb-4) on endothelial function using diabetic human induced pluripotent stem cell derived endothelial cells (dia-hiPSC-ECs) as a model. The results showed that Tb-4 improved endothelial dysfunction by enhancing cell viability, reducing senescence and endothelin-1 production, and improving angiogenic potency in diabetes.

STEM CELL RESEARCH & THERAPY (2022)

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Article Endocrinology & Metabolism

Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression Network Analysis

Shoumeng Yan et al.

Summary: This study identified key lncRNAs related to blood glucose through weighted gene co-expression network analysis, providing important references for potential biomarkers of type 2 diabetes mellitus.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Critical Care Medicine

Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Tingting Pan et al.

Summary: This study investigated the metabolic characteristics and immunomodulatory pathways of polymorphonuclear neutrophils (PMNs) during sepsis. The study found significant changes in glycolysis and the mTOR/HIF-1 alpha signaling pathway during sepsis. The Warburg effect was also altered in septic patients. Glycolysis was found to regulate PMNs' chemotaxis and phagocytosis functions, and lactate dehydrogenase A (LDHA) downregulation played a key role in inhibiting glycolysis in PMNs. The PI3K/Akt-HIF-1 alpha pathway was involved in LDHA expression and influenced PMNs' chemotaxis and phagocytosis functions.

CRITICAL CARE (2022)

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Article Endocrinology & Metabolism

Long Noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy

Rakesh Radhakrishnan et al.

Summary: This study demonstrates that LncRNA MALAT1 plays a role in regulating antioxidant defense in diabetic retinopathy via the Keap1-Nrf2 pathway.

DIABETES (2021)

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Article

An overview of diabetic retinopathy and other ocular complications of diabetes mellitus

Mahesh Seewoodhary

Nursing standard (Royal College of Nursing (Great Britain) : 1987) (2021)

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Article Biochemistry & Molecular Biology

LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis

Guo-Qun Chen et al.

Summary: This study found that FTX is upregulated in CRC and its knockdown or overexpression of miR-590-5p can inhibit the proliferation, migration, and invasion of CRC cells. Inhibition of miR-590-5p can reverse the inhibitory effect of FTX on the progression of CRC. Additionally, FTX silencing can inhibit the expression of migration and invasion-related proteins in CRC cells, indicating its potential as a novel strategy for CRC treatment.

BIOCHEMICAL GENETICS (2021)

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Article Endocrinology & Metabolism

Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes

Jae-Seung Yun et al.

Summary: With advancements in diabetes care, incident cardiovascular disease in patients with type 2 diabetes mellitus has decreased. Challenges remain due to CVD being a major cause of death in diabetic patients. Research focuses on reducing cardiovascular risk in T2DM through lifestyle modifications and therapeutic approaches.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Cardiac & Cardiovascular Systems

N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

Ye-shi Chen et al.

Summary: N6-methyladenosine (m(6)A) is the most abundant and prevalent epigenetic modification of mRNA in mammals, regulating the fate of target mRNAs by influencing splicing, translation, and decay. Its important role in cardiovascular diseases, such as cardiac remodeling, heart failure, atherosclerosis, and congenital heart disease, has been highlighted in recent studies, although the exact mechanisms are not fully elucidated.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2021)

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Article Oncology

Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/ PPAR gamma signaling pathway

Liqiang Chen et al.

Summary: The study found that metformin can alleviate bevacizumab-induced endothelial injury, potentially through activation of GDF15 and the PI3K/AKT/FOXO/PPARγ signaling pathway.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Pharmacology & Pharmacy

The Function of LncRNA FTX in Several Common Cancers

Yexiang Lin et al.

Summary: LncRNA FTX is abnormally increased in various tumors, while its expression level decreases in certain diseases. FTX may be an important regulatory factor and a potential therapeutic target in cancers.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Ophthalmology

The potential role of m6A RNA methylation in diabetic retinopathy

Nidhi Kumari et al.

Summary: Diabetic retinopathy, a major microvascular complication of diabetes affecting most individuals, may potentially involve the modification of RNA through m6A in disease progression mechanisms, although its specific role remains unclear.

EXPERIMENTAL EYE RESEARCH (2021)

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Article Medicine, Research & Experimental

The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension

Yuhan Qin et al.

Summary: This study demonstrates that METTL3 plays a crucial role in the development of hypoxia-induced PASMCs proliferation by mediating m(6)A modification on PTEN mRNA. The METTL3/YTHDF2/PTEN axis represents a significant pathway in HPH, offering a new potential therapeutic target.

LIFE SCIENCES (2021)

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Review Endocrinology & Metabolism

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Daniel Ferguson et al.

Summary: NAFLD is the most prevalent liver disease worldwide, with no approved pharmacological therapies available. The spectrum of severity ranges from steatosis to NASH, which is linked to increased risks of liver cancer and cirrhosis. Therefore, a holistic approach and ongoing therapeutic options are necessary to address the global health burden of these diseases.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Endocrinology & Metabolism

Treatment of type 2 diabetes: challenges, hopes, and anticipated successes

Michael A. Nauck et al.

Summary: This review explores novel targets and mechanisms for the treatment of type 2 diabetes, including GLP-1 receptor agonists, insulin therapies, adiponectin, and potential clinical applications of various compounds. These approaches aim to optimize treatment outcomes for well-defined subgroups of type 2 diabetes and facilitate personalized treatment approaches.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Article Multidisciplinary Sciences

LncRNA NEAT1 regulated diabetic retinal epithelial-mesenchymal transition through regulating miR-204/SOX4 axis

Yang Yang et al.

Summary: NEAT1 regulated the development of EMT in diabetic retinopathy through the miR-204/SOX4 pathway, providing a reference for clinical prevention and treatment.

PEERJ (2021)

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Review Chemistry, Multidisciplinary

Emerging Targets in Type 2 Diabetes and Diabetic Complications

Sevgican Demir et al.

Summary: Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance and high blood sugar levels, with complications affecting various organs. Effective therapies are lacking, and further research on novel treatment targets is needed to pave the way for potential prevention and treatment of this disease.

ADVANCED SCIENCE (2021)

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Article Respiratory System

The role of RNA m6A methylation in the regulation of postnatal hypoxia-induced pulmonary hypertension

Shanshan Xu et al.

Summary: The study revealed that postnatal exposure to hypoxia can lead to pulmonary hypertension (PH) which may persist into adulthood. The m6A modification plays a crucial role in the development of PH, with its level changes potentially affecting the expression of PH-related genes and lung development.

RESPIRATORY RESEARCH (2021)

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Review Pharmacology & Pharmacy