Recent updates on thienopyrimidine derivatives as anticancer agents

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they are structural analogs of purines. Thienopyrimidine derivatives have various biological activities. The current review discusses different synthetic methods for the preparation of heterocyclic thienopyrimidine derivatives. It also highlights the most recent research on the anticancer effects of thienopyrimidines through the inhibition of various enzymes and pathways, which was published within the last 9 years. [GRAPHICS] .

Automated summary

Thienopyrimidine derivatives occupy a special place in fused pyrimidine compounds due to their structural analogs of purines. They have significant biological activities and are widely used in medicinal chemistry. This review discusses various synthetic methods for preparing heterocyclic thienopyrimidine derivatives and highlights recent research on their anticancer effects through enzyme and pathway inhibition in the past 9 years.